Novel, chemokine CCR2 covalent negative allosteric modulator (NAM) (apparent pKi values at CCR2 are 8.7 and 9.2 (after 4h), where a Ki shift indicates a covalent mode of action). Binds intracellularly and forms a covalent bond with one of three proximal cysteine residues of CCR2.
Sold under license from the Oncode Institute and Universiteit Leiden
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Water soluble formulation of dexamethasone: synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Suitable for cell culture.
Understanding purity and quality - a guide for life scientists
