Novel, chemokine CCR2 covalent negative allosteric modulator (NAM) (apparent pKi values at CCR2 are 8.7 and 9.2 (after 4h), where a Ki shift indicates a covalent mode of action). Binds intracellularly and forms a covalent bond with one of three proximal cysteine residues of CCR2.
Sold under license from the Oncode Institute and Universiteit Leiden
Synthetic glucocorticoid with potent anti-inflammatory actions. Induces hMSC differentiation. Apoptosis inducer. Water soluble and suitable for cell culture.
Understanding purity and quality - a guide for life scientists
