G protein coupled receptors
G-protein-coupled receptors (also known as GPCRs, transmembrane receptors, or 7-TM receptors), are integral membrane proteins that contain seven membrane-spanning domains (helices). They are coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway. Researchers can save up to 50% on GPCR receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.
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D-AP5 (HB0225)
Description:Selective, competitive NMDA receptor antagonist. Inhibits NMDAR-synaptic plasticity.
Purity:>99%
PPDA (HB0531)
Description:Potent GluN2C / GluN2D subunit selective NMDA receptor antagonist
Purity:>98%
Ro 25-6981 maleate (HB0554)
Description:Selective negative allosteric modulator of GluN2B (NR2B) containing NMDARs
Purity:>98%
TCN 201 (HB0604)
Description:Potent, non-competitive GluN2A subunit selective NMDA receptor antagonist
Purity:>99%
UBP709 (HB9204)
Description:NMDAR pan-PAM that potentiates all GluN2 subunits. Enhances LTD and decreases LTP.Â
Purity:>98%