Product overview
| Name | PEAQX (NVP-AAM 077) |
| Description | Potent, competitive NMDA receptor antagonist |
| Alternative names | NVP-AAM 007 |
| Purity | >98% |
| Customer comments | It works! PEAQX (NVP-AAM 077) blocks a considerable portion of the NMDA-mediated current in whole cell patch set-up. Verified customer, Rutgers University |
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Biological Data
| Biological description | Potent and competitive NMDA receptor antagonist. Binds at the glutamate site. Shows some selectivity (~7-10-fold) for GluN1/2A (NR1/2A) over GluN1/2B (NR1/2B) subunit containing receptors (IC50 values are 31 and 215 nM at GluN1/2A and GluN1/2B respectively). Shows anticonvulsant activity. Active in vivo. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt |
| Molecular Weight | 542.14 |
| Chemical structure | ![PEAQX [459836-30-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2841.png "PEAQX [459836-30-7]") |
| Molecular Formula | C17H13BrN3Na4O5P |
| CAS Number | 459836-30-7 |
| PubChem identifier | 101043065 |
| SMILES | CC(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)[O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+] |
| InChi | InChI=1S/C17H17BrN3O5P.4Na/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;/q;4*+1/p-4 |
| InChiKey | QBVOZIDKUFSQIL-UHFFFAOYSA-J |
References for PEAQX (NVP-AAM 077)
References are publications that support the biological activity of the product
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The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.
Morales and Spear (2014) Psychopharmacology (Berl). 231(8) : 1797-807 -
Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: Implications for studies of sy
Frizelle et al (2006) Mol Pharmacol. 70(3) : 1022-32 -
5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.
Auberson et al (2002) Bioorg Med Chem Lett 12(7) : 1099-102.
Publications
These publications cite the use of PEAQX (NVP-AAM 077) purchased from Hello Bio:
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Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure
Polli et al. (2020) Mol Neurobiol 57(4) : 2002-2020PubMedID: 31916029 -
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Lind et al (2017) Proc Natl Acad Sci U S A 114(33) : 6942-6951PubMedID: 28760974 -
Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.
Lind et al (2017) Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1707752114 : Epub ahead of printPubMedID: 28760974
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