PEAQX (NVP-AAM 077)

(HB2841)
Technical documents: SDS Datasheet

Product overview

Name PEAQX (NVP-AAM 077)
Description Potent, competitive NMDA receptor antagonist
Alternative names NVP-AAM 007
Purity >98%
Customer comments

It works! PEAQX (NVP-AAM 077) blocks a considerable portion of the NMDA-mediated current in whole cell patch set-up. Verified customer, Rutgers University

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PEAQX (NVP-AAM 077): Scientist Approved

Biological Data

Biological description

Potent and competitive NMDA receptor antagonist. Binds at the glutamate site.

Shows some selectivity (~7-10-fold) for GluN1/2A (NR1/2A) over GluN1/2B (NR1/2B) subunit containing receptors (IC50 values are 31 and 215 nM at GluN1/2A and GluN1/2B respectively).

Shows anticonvulsant activity. Active in vivo.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name [[[(1S)-1-(4-Bromophenyl)ethyl]amino](1,2,3,4-tetrahydro-2,3-dioxo-5-quinoxalinyl)methyl] phosphonic acid tetrasodium salt
Molecular Weight 542.14
Chemical structure PEAQX [459836-30-7] Chemical Structure
Molecular Formula C17H13BrN3Na4O5P
CAS Number 459836-30-7
PubChem identifier 101043065
SMILES CC(C1=CC=C(C=C1)Br)NC(C2=C3C(=CC=C2)N=C(C(=N3)[O-])[O-])P(=O)([O-])[O-].[Na+].[Na+].[Na+].[Na+]
InChi InChI=1S/C17H17BrN3O5P.4Na/c1-9(10-5-7-11(18)8-6-10)19-17(27(24,25)26)12-3-2-4-13-14(12)21-16(23)15(22)20-13;;;;/h2-9,17,19H,1H3,(H,20,22)(H,21,23)(H2,24,25,26);;;;/q;4*+1/p-4
InChiKey QBVOZIDKUFSQIL-UHFFFAOYSA-J

References for PEAQX (NVP-AAM 077)

References are publications that support the biological activity of the product
  • The effects of an acute challenge with the NMDA receptor antagonists, MK-801, PEAQX, and ifenprodil, on social inhibition in adolescent and adult male rats.

    Morales and Spear (2014) Psychopharmacology (Berl). 231(8) : 1797-807
  • Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B NMDA receptors: Implications for studies of sy

    Frizelle et al (2006) Mol Pharmacol. 70(3) : 1022-32
  • 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition.

    Auberson et al (2002) Bioorg Med Chem Lett 12(7) : 1099-102.
Publications
These publications cite the use of PEAQX (NVP-AAM 077) purchased from Hello Bio:
  • Cellular and Molecular Changes in Hippocampal Glutamate Signaling and Alterations in Learning, Attention, and Impulsivity Following Prenatal Nicotine Exposure

    Polli et al. (2020) Mol Neurobiol 57(4) : 2002-2020
    PubMedID: 31916029
  • Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

    Lind et al (2017) Proc Natl Acad Sci U S A 114(33) : 6942-6951
    PubMedID: 28760974
  • Structural basis of subunit selectivity for competitive NMDA receptor antagonists with preference for GluN2A over GluN2B subunits.

    Lind et al (2017) Proc Natl Acad Sci U S A. doi: 10.1073/pnas.1707752114 : Epub ahead of print
    PubMedID: 28760974

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