Memantine hydrochloride

Technical documents: SDS Datasheet

Product overview

Name Memantine hydrochloride
Alternative names Axura, Akatinol, Namenda, Ebixa, Abixa, Memox
Purity >98%
Description Non-competitive NMDA receptor antagonist
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Memantine inhibition of evoked NMDAR mediated EPSCs
Memantine hydrochloride: Scientist Approved
Memantine hydrochloride product vial image | Hello Bio

Biological Data

Biological description

Non-competitive NMDA receptor antagonist (IC50 = 1.25 μM). Binds to ion channel site.

Shows low affinity but has rapid blocking and unblocking ability at the NMDAR.

Selectively blocks extrasynaptic NMDARs.

Enhances hippocampal long-term potentiation (LTP) and reverses LTP suppression.

Improves cognitive function and shows anti-Alzheimer's activity.

Application notes

The voltage sensitive NMDA receptor antagonist memantine is effective at concentrations of 10-100 µM. In CA1 hippocampal neurons held at – 30 Mv, Hello Bio memantine (at 100 µM) gradually inhibited evoked NMDA receptor mediated excitatory currents over time (see Fig 1 above).


#Protocol 1: Assay evoked NMDAR currents at -30 mV (used for memantine)

  • NMDAR currents were recorded via whole cell voltage clamp recordings of CA1 pyramidal neurons from the rat hippocampal brain slice and evoked via a stimulating electrode placed in the CA3 region to stimulate the Schaffer collateral pathway.
  • Each NMDAR current was evoked via a single square (150 µs) pulse every 10 sec at a stimulus intensity that gave a reliable NMDAR current.
  • Neurons were constantly held at -30 mV and NMDAR currents recorded in response to continual bath applications of NMDAR antagonists.
  • All NMDAR recordings were made in the presence of GABAA-R and AMPA-R antagonists.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name 3,5-Dimethyl-tricyclo[,7]decan-1-amine hydrochloride
Molecular Weight 215.77
Chemical structure Memantine hydrochloride  [41100-52-1] Chemical Structure
Molecular Formula C12H21N.HCl
CAS Number 41100-52-1
PubChem identifier 181458
InChi InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
MDL number MFCD00214336
Appearance White solid

References for Memantine hydrochloride

References are publications that support the biological activity of the product
  • Memantine selectively blocks extrasynaptic NMDA receptors in rat substantia nigra dopamine neurons.

    Wu and Johnson (2015) Brain Res. 1603 : 1-7
  • Effects of memantine on hippocampal long-term potentiation, gamma activity, and sensorimotor gating in freely moving rats.

    Ma et al (2015) Neurobiol Aging 36(9) : 2544-54
  • Memantine binding to a superficial site on NMDA receptors contributes to partial trapping.

    Kotermanski SE et al (2009) J Physiol 587(Pt 19) : 4589-604.
  • The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2/579 and other amino-alkyl-cyclohexanes antagonise 5-HT(3) receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner.

    Rammes G et al (2001) Neurosci Lett 306(1-2) : 81-4.
  • Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist--a review of preclinical data.

    Parsons CG et al (1999) Neuropharmacology 38(6) : 735-67.

5 Item(s)

These publications cite the use of Memantine hydrochloride purchased from Hello Bio:
  • Specific pathogenic mutations in the M3 domain of the GluN1 subunit regulate the surface delivery and pharmacological sensitivity of NMDA receptors

    Kolcheva M et al (2021) Neuropharmacology 189 : 108528
    PubMedID: 33773999
  • Functional and pharmacological properties of triheteromeric GluN1/2B/2D NMDA receptors

    Yi F et al (2019) J Physiol 597(22) : 5495-5514
    PubMedID: 31541561

2 Item(s)