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Images (R)-CPP product vial image | Hello Bio
(R)-CPP product vial image | Hello Bio Biological Data Biological description Potent NMDA receptor antagonist. More active enantiomer of (RS)-CPP . Selective for GluN2A subtypes over GluN2B, GluN2C and GluN2D subtypes (Ki values are 41 nM, 0.27, 0.63 and 1.99 μM respectively). Blocks NMDA receptor-mediated EPSCs. Shows antinociceptive effect. Active in vivo.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3-((R )-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Chemical structure
Molecular Formula C8 H17 N2 O5 P
PubChem identifier 6603754
SMILES C1CN(C[C@@H](N1)C(=O)O)CCCP(=O)(O)O
InChi InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1
InChiKey CUVGUPIVTLGRGI-SSDOTTSWSA-N
References for (R)-CPP References are publications that support the biological activity of the product
Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells. Cho T et al (2013) PLoS One 8(10) : e76860. Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP. Carli M et al (2011) Psychopharmacology (Berl) 214(3) : 625-37. Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid. Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.
Publications
These publications cite the use of (R)-CPP purchased from Hello Bio:
Examination of diurnal variation and sex differences in hippocampal neurophysiology and spatial memory Goode et al (2022) BioRxiv https://www.biorxiv.org/content/10.1101/2022.03.12.484083v1 : .
Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus Oberle HM et al (2022) Elife 10 Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons Banghar et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441199 : doi
Synaptic mechanisms of top-down control by the auditory cortico-collicular pathway Apostolides et al (2021) bioRxiv https://doi.org/10.1101/2021.07.26.453816 : doi
Potent NMDA receptor antagonist
![(R)-CPP [126453-07-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0021.png "(R)-CPP [126453-07-4]")
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