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Product overview

Name (R)-CPP
Customer comments

Good quality and good price Verified customer, Seoul National University

Description Potent NMDA receptor antagonist
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(R)-CPP product vial image | Hello Bio

Biological Data

Biological description

Potent NMDA receptor antagonist. More active enantiomer of (RS)-CPP. Selective for GluN2A subtypes over GluN2B, GluN2C and GluN2D subtypes (Ki values are 41 nM, 0.27, 0.63 and 1.99 μM respectively). Blocks NMDA receptor-mediated EPSCs. Shows antinociceptive effect. Active in vivo.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name 3-((R)-2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Molecular Weight 252.21
Chemical structure (R)-CPP  [126453-07-4] Chemical Structure
Molecular Formula C8H17N2O5P
CAS Number 126453-07-4
PubChem identifier 6603754
InChi InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)/t7-/m1/s1
Formulation White solid

References for (R)-CPP

References are publications that support the biological activity of the product
  • Long-term potentiation promotes proliferation/survival and neuronal differentiation of neural stem/progenitor cells.

    Cho T et al (2013) PLoS One 8(10) : e76860.
  • Sertindole restores attentional performance and suppresses glutamate release induced by the NMDA receptor antagonist CPP.

    Carli M et al (2011) Psychopharmacology (Berl) 214(3) : 625-37.
  • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.

    Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.

3 Item(s)

These publications cite the use of (R)-CPP purchased from Hello Bio:
  • Examination of diurnal variation and sex differences in hippocampal neurophysiology and spatial memory

    Goode et al (2022) BioRxiv https://www.biorxiv.org/content/10.1101/2022.03.12.484083v1 : .
  • Synaptic mechanisms of top-down control in the non-lemniscal inferior colliculus

    Oberle HM et al (2022) Elife 10
    PubMedID: 34989674
  • Convergent, functionally independent signaling by mu and delta opioid receptors in hippocampal parvalbumin interneurons

    Banghar et al (2021) bioRxiv https://doi.org/10.1101/2021.04.23.441199 : doi
  • Synaptic mechanisms of top-down control by the auditory cortico-collicular pathway

    Apostolides et al (2021) bioRxiv https://doi.org/10.1101/2021.07.26.453816 : doi

4 Item(s)