Technical documents: SDS CoA Datasheet

Product overview

Name (RS)-CPP
Description Potent, selective, competitive NMDA receptor antagonist
Write Your Own Review
You're reviewing:(RS)-CPP
Rate this item:

Biological Data

Biological description Potent, selective and competitive NMDA receptor antagonist. Shows anticonvulsant activity.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Chemical name (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Molecular Weight 252.21
Chemical structure (RS)-CPP  [100828-16-8] Chemical Structure
Molecular Formula C8H17N2O5P
CAS Number 100828-16-8
PubChem identifier 1228
InChi InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)
MDL number MFCD00055136

References for (RS)-CPP

References are publications that support the biological activity of the product
  • CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

    Lehmann J et al (1987) J Pharmacol Exp Ther 240(3) : 737-46.
  • Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.

    Harris EW et al (1986) Brain Res 382(1) : 174-7.
  • CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

    Davies J et al (1986) Brain Res 382(1) : 169-73.
These publications cite the use of (RS)-CPP purchased from Hello Bio:
  • Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al

    Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
    PubMedID: 34048091

1 Item