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Technical documents: SDS CoA Datasheet

Product overview

Name (RS)-CPP
Description Potent, selective, competitive NMDA receptor antagonist
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(RS)-CPP product vial image | Hello Bio

Biological Data

Biological description

Potent, selective and competitive NMDA receptor antagonist which reversibly binds to the glutamate binding site. Crosses the blood brain barrier and is active in vivo. Shows various effects (e.g. supresses seizure activity, interferes with addiction paradigms, blocks LTP and LTD and impairs learning and memory). (R)-CPP also available.

Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid
Molecular Weight 252.21
Chemical structure (RS)-CPP  [100828-16-8] Chemical Structure
Molecular Formula C8H17N2O5P
CAS Number 100828-16-8
PubChem identifier 1228
InChi InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)
MDL number MFCD00055136

References for (RS)-CPP

References are publications that support the biological activity of the product
  • Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.

    Gemperline E et al (2014) Analytical methods : advancing methods and applications 6 : 6389-6396
  • CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

    Lehmann J et al (1987) J Pharmacol Exp Ther 240(3) : 737-46.
  • Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.

    Harris EW et al (1986) Brain Res 382(1) : 174-7.
  • CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

    Davies J et al (1986) Brain Res 382(1) : 169-73.

4 Item(s)

These publications cite the use of (RS)-CPP purchased from Hello Bio:
  • Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAA receptors of A17 amacrine cells in the rat retina

    Beltran-Matas P et al (2022) Eur J Neurosci 55(6) : 1442-1470
    PubMedID: 35236011
  • FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony

    Huber et al (2021) bioRxiv https://doi.org/10.1101/2021.06.25.449490 : doi
  • Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice

    Fusilier AR et al (2021) Neurobiol Dis 158 : 105454
    PubMedID: 34333153
  • Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

    Zhang Z et al (2021) Elife 10
    PubMedID: 34617509
  • Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al

    Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
    PubMedID: 34048091

5 Item(s)