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(RS)-CPP

Name: (RS)-CPP
Brand: Hello Bio
SKU: HB0036
Price: 78 USD
Availability: InStock
Rating: 100 (2 reviews)

(HB0036)

Publications (5)

Technical documents: SDS CoA Datasheet

Product overview

Name

(RS)-CPP

Description

Potent, selective, competitive NMDA receptor antagonist

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews (2) Publications (5) References (4) Frequently bought together

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Images

(RS)-CPP product vial image | Hello Bio

Biological Data

Biological description

Potent, selective and competitive NMDA receptor antagonist which reversibly binds to the glutamate binding site. Crosses the blood brain barrier and is active in vivo. Shows various effects (e.g. supresses seizure activity, interferes with addiction paradigms, blocks LTP and LTD and impairs learning and memory). (R)-CPP also available.

Solubility & Handling

Storage instructions

Room temperature (desiccate)

Solubility overview

Soluble in water (100mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Chemical name

(RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid

Molecular Weight

252.21

Chemical structure

Molecular Formula

C₈H₁₇N₂O₅P

CAS Number

100828-16-8

PubChem identifier

1228

SMILES

C1CN(CC(N1)C(=O)O)CCCP(=O)(O)O

InChi

InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15)

InChiKey

CUVGUPIVTLGRGI-UHFFFAOYSA-N

MDL number

MFCD00055136

Technical guides

NMDA receptor (NMDAR) mini-review

NMDA receptor (NMDAR) associated proteins mini-review

Ionotropic glutamate receptor nomenclature guide

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for (RS)-CPP

References are publications that support the biological activity of the product

Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.
Gemperline E et al (2014) Analytical methods : advancing methods and applications 6 : 6389-6396
Read more (PubMedID: 25663848)
CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Lehmann J et al (1987) J Pharmacol Exp Ther 240(3) : 737-46.
Read more (PubMedID: 2882014)
Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.
Harris EW et al (1986) Brain Res 382(1) : 174-7.
Read more (PubMedID: 2876750)
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.
Davies J et al (1986) Brain Res 382(1) : 169-73.
Read more (PubMedID: 2876749)

Publications

Submit Yours Now

These publications cite the use of (RS)-CPP purchased from Hello Bio:

Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina
Beltran-Matas P et al (2022) Eur J Neurosci 55(6) : 1442-1470
PubMedID: 35236011
FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony
Huber et al (2021) bioRxiv https://doi.org/10.1101/2021.06.25.449490 : doi
Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice
Fusilier AR et al (2021) Neurobiol Dis 158 : 105454
PubMedID: 34333153
Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP
Zhang Z et al (2021) Elife 10
PubMedID: 34617509
Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al
Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)
PubMedID: 34048091

Grouped product items
Order: HB0036
Pack	Price	Qty
5mg	$78
10mg	$144
50mg	$537
100mg	$791

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Potent, selective, competitive NMDA receptor antagonist

(RS)-CPP

Product overview

Images

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for (RS)-CPP

Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.

CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina

FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony

Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al

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(RS)-CPP

Product overview

Images

(RS)-CPP product vial image | Hello Bio

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for (RS)-CPP

Measurement of NMDA Receptor Antagonist, CPP, in Mouse Plasma and Brain Tissue Following Systematic Administration Using Ion-Pair LCMS/MS.

CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.

Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.

CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.

Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABAA receptors of A17 amacrine cells in the rat retina

FMRP regulates experience-dependent maturation of callosal synaptic connections and bilateral cortical synchrony

Dysregulated clock gene expression and abnormal diurnal regulation of hippocampal inhibitory transmission and spatial memory in amyloid precursor protein transgenic mice

Experience-dependent weakening of callosal synaptic connections in the absence of postsynaptic FMRP

Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al

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Inhibitory inputs to an inhibitory interneuron: Spontaneous postsynaptic currents and GABA_A receptors of A17 amacrine cells in the rat retina