Product overview
| Name | (RS)-CPP |
| Description | Potent, selective, competitive NMDA receptor antagonist |
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Biological Data
| Biological description | Potent, selective and competitive NMDA receptor antagonist. Shows anticonvulsant activity. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (RS)-3-(2-Carboxypiperazin-4-yl)-propyl-1-phosphonic acid |
| Molecular Weight | 252.21 |
| Chemical structure | ![(RS)-CPP [100828-16-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0036.png "(RS)-CPP [100828-16-8]") |
| Molecular Formula | C8H17N2O5P |
| CAS Number | 100828-16-8 |
| PubChem identifier | 1228 |
| SMILES | C1CN(CC(N1)C(=O)O)CCCP(=O)(O)O |
| InChi | InChI=1S/C8H17N2O5P/c11-8(12)7-6-10(4-2-9-7)3-1-5-16(13,14)15/h7,9H,1-6H2,(H,11,12)(H2,13,14,15) |
| InChiKey | CUVGUPIVTLGRGI-UHFFFAOYSA-N |
| MDL number | MFCD00055136 |
References for (RS)-CPP
References are publications that support the biological activity of the product
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CPP, a selective N-methyl-D-aspartate (NMDA)-type receptor antagonist: characterization in vitro and in vivo.
Lehmann J et al (1987) J Pharmacol Exp Ther 240(3) : 737-46. -
Action of 3-((+/-)-2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid (CPP): a new and highly potent antagonist of N-methyl-D-aspartate receptors in the hippocampus.
Harris EW et al (1986) Brain Res 382(1) : 174-7. -
CPP, a new potent and selective NMDA antagonist. Depression of central neuron responses, affinity for [3H]D-AP5 binding sites on brain membranes and anticonvulsant activity.
Davies J et al (1986) Brain Res 382(1) : 169-73.
Publications
These publications cite the use of (RS)-CPP purchased from Hello Bio:
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Different glutamate sources and endogenous co-agonists activate extrasynaptic NMDA receptors on amacrine cells of the rod pathway microcircuitBeltran-Matas et al
Beltran-Matas et al (2021) Eur J Neurosci. : 54(2)PubMedID: 34048091
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