Figure 1. UBP709 is a pan-PAM that potentiates LTD
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 1. UBP709 is a pan-PAM that potentiates LTD
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Biological Data
Biological description
NMDAR pan-PAM that potentiates all GluN2 subunits. First reported NMDAR PAM to enhance LTD and decrease LTP: in P14 hippocampal slices, the pan-PAM UBP709 potentiates the induction of LTD and reduces induction of LTP in a concentration-dependent manner. UBP709 also permits induction of LTD by 10 Hz stimulation, dependent on co-activation of GluN2B containing NMDARs and mGluRs.
Solubility & Handling
Storage instructions
Room temperature
Solubility overview
Soluble in DMSO (100 mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
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