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UBP709

(HB9204)
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Product overview

Name UBP709
Alternative names Compound 19c
Purity >98%
Description

NMDAR pan-PAM that potentiates all GluN2 subunits. Enhances LTD and decreases LTP. 

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (2) Frequently bought together
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Figure 1. UBP709 is a pan-PAM that potentiates LTD

Figure 1. UBP709 is a pan-PAM that potentiates LTD

France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP

Figure 2. UBP709 is a pan-PAM that inhibits LTP

France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 1. UBP709 is a pan-PAM that potentiates LTD

Figure 1. UBP709 is a pan-PAM that potentiates LTD

France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP

Figure 2. UBP709 is a pan-PAM that inhibits LTP

France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840

Biological Data

Biological description

NMDAR pan-PAM that potentiates all GluN2 subunits. First reported NMDAR PAM to enhance LTD and decrease LTP: in P14 hippocampal slices, the pan-PAM UBP709 potentiates the induction of LTD and reduces induction of LTP in a concentration-dependent manner. UBP709 also permits induction of LTD by 10 Hz stimulation, dependent on co-activation of GluN2B containing NMDARs and mGluRs.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 9-butylphenanthrene-3-carboxylic acid
Molecular Weight 278.35
Chemical structure Chemical Structure
Molecular Formula C19H18O2
PubChem identifier 88563705
SMILES CCCCC1=CC2=C(C=C(C=C2)C(=O)O)C3=CC=CC=C31
InChi InChI=1S/C19H18O2/c1-2-3-6-13-11-14-9-10-15(19(20)21)12-18(14)17-8-5-4-7-16(13)17/h4-5,7-12H,2-3,6H2,1H3,(H,20,21)
InChiKey RPHNFYJPUJYHFP-UHFFFAOYSA-N
Appearance White solid

References for UBP709

References are publications that support the biological activity of the product

  • Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators

    France et al (2022) Neuropharmacology : 202:108840
    Read more (PubMedID: 34678377)

  • Synthesis of a Series of Novel 3,9-Disubstituted Phenanthrenes as Analogues of Known NMDA Receptor Allosteric Modulators

    Irvine et al (2015) Synthesis (Stuttg) . :
    Read more (PubMedID: 26568642)

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10mg
$186
50mg
$767

NMDAR pan-PAM that potentiates all GluN2 subunits. Enhances LTD and decreases LTP. 

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