Figure 1. UBP709 is a pan-PAM that potentiates LTD
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 1. UBP709 is a pan-PAM that potentiates LTD
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Figure 2. UBP709 is a pan-PAM that inhibits LTP
France et al Neuropharmacology, 2022 Jan 1, 202: 108840, doi: 10.1016/jneuropharm.2021.108840
Biological Data
Biological description
NMDAR pan-PAM that potentiates all GluN2 subunits. First reported NMDAR PAM to enhance LTD and decrease LTP: in P14 hippocampal slices, the pan-PAM UBP709 potentiates the induction of LTD and reduces induction of LTP in a concentration-dependent manner. UBP709 also permits induction of LTD by 10 Hz stimulation, dependent on co-activation of GluN2B containing NMDARs and mGluRs.
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
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