Product overview

Name PPDA
Description Potent GluN2C / GluN2D subunit selective NMDA receptor antagonist
Purity >98%
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Biological Data

Biological description Potent GluN2C and GluN2D subunit selective NMDA receptor antagonist (Ki values are 96, 125 nM and 0.31, 0.55 µM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively). Shows protective effects against Alzheimer's disease.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in NaOH(aq) (50mM, 2eq. NaOH) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (2S*,3R*)-1-(Phenanthren-2-carbonyl )piperazine-2,3-dicarboxylic acid
Molecular Weight 378.38
Chemical structure PPDA  [684283-16-7] Chemical Structure
Molecular Formula C21H18N2O5
CAS Number 684283-16-7
PubChem identifier 90488770
SMILES O=C(C2=CC=C3C(C=CC4=C3C=CC=C4)=C2)N1[C@@H]([C@](O)=O)[C@@H]([C@](O)=O)NCC1.O=C(C6=CC=C7C(C=CC8=C7C=CC=C8)=C6)N5[C@H](C(O)=O)[C@H](C(O)=O)NCC5
Source Synthetic
InChi InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m1/s1
InChiKey FAQARVDXAFZICA-QVUSPSOHSA-N
Appearance White solid

References for PPDA

References are publications that support the biological activity of the product
  • The preventive effect of NR2B and NR2D-containing NMDAR antagonists on Aβ-induced LTP disruption in the dentate gyrus of rats.

    Zhang J et al (2013) Metab Brain Dis 28(4) : 697-704.
  • Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket.

    Kinarsky L et al (2005) J Pharmacol Exp Ther 313(3) : 1066-74.
  • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.

    Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.