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PPDA

(HB0531)
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Product overview

Name PPDA
Purity >98%
Description Potent GluN2C / GluN2D subunit selective NMDA receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (4) Reviews References (3) Frequently bought together
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Images

PPDA product vial image | Hello Bio
PPDA product vial image | Hello Bio

PPDA product vial image | Hello Bio

PPDA product vial image | Hello Bio

Biological Data

Biological description Potent GluN2C and GluN2D subunit selective NMDA receptor antagonist (Ki values are 96, 125 nM and 0.31, 0.55 µM for GluN2C, GluN2D, GluN2B and GluN2A subunits respectively). Shows protective effects against Alzheimer's disease.

Solubility & Handling

Solubility overview Soluble in NaOH(aq) (50mM, 2eq. NaOH) or DMSO (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (2S*,3R*)-1-(Phenanthren-2-carbonyl )piperazine-2,3-dicarboxylic acid
Molecular Weight 378.38
Chemical structure PPDA [684283-16-7] Chemical Structure
Molecular Formula C21H18N2O5
CAS Number 684283-16-7
PubChem identifier 90488770
SMILES O=C(C2=CC=C3C(C=CC4=C3C=CC=C4)=C2)N1[C@@H]([C@](O)=O)[C@@H]([C@](O)=O)NCC1.O=C(C6=CC=C7C(C=CC8=C7C=CC=C8)=C6)N5[C@H](C(O)=O)[C@H](C(O)=O)NCC5
Source Synthetic
InChi InChI=1S/C21H18N2O5/c24-19(23-10-9-22-17(20(25)26)18(23)21(27)28)14-7-8-16-13(11-14)6-5-12-3-1-2-4-15(12)16/h1-8,11,17-18,22H,9-10H2,(H,25,26)(H,27,28)/t17-,18+/m1/s1
InChiKey FAQARVDXAFZICA-QVUSPSOHSA-N
Appearance White solid

References for PPDA

References are publications that support the biological activity of the product

  • The preventive effect of NR2B and NR2D-containing NMDAR antagonists on Aβ-induced LTP disruption in the dentate gyrus of rats.

    Zhang J et al (2013) Metab Brain Dis 28(4) : 697-704.
    Read more (PubMedID: 23975536)

  • Identification of subunit- and antagonist-specific amino acid residues in the N-Methyl-D-aspartate receptor glutamate-binding pocket.

    Kinarsky L et al (2005) J Pharmacol Exp Ther 313(3) : 1066-74.
    Read more (PubMedID: 15743930)

  • Structure-activity analysis of a novel NR2C/NR2D-preferring NMDA receptor antagonist: 1-(phenanthrene-2-carbonyl) piperazine-2,3-dicarboxylic acid.

    Feng B et al (2004) Br J Pharmacol 141(3) : 508-16.
    Read more (PubMedID: 14718249)

3 Item(s)

Related Products
Grouped product items
Order: HB0531
Pack PriceQty
10mg
$137
50mg
$562
Potent GluN2C / GluN2D subunit selective NMDA receptor antagonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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