Highly potent and selective GluN2C/2D NMDAR antagonist (Ki values are 9 nM and 7 nM at GluN2C and GluN2D respectively). PPDA derivative. UBP1700 is one of the most potent GluN2 antagonists reported to date which shows ~50 to 60 fold selectivity for GluN2C/2D over GluN2A and ~40 to 50 fold selectivity for GluN2C/2D over GluN2B subunits. UBP1700 displays similar selectivity for GluN2C/2D as QNZ46 and DQP-1105 but has higher potency, thus is likely to inhibit receptors more effectively than these compounds where Glu2D-containing NMDARs are located (e.g. peri- and extrasynaptic spaces).
Solubility & Handling
Solubility overview
Soluble in DMSO (100 mM), in water with 1eq NaOH (50 mM) and in basic aqueous buffer (50 mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Understanding purity and quality - a guide for life scientists
