UBP1700

Highly potent and selective GluN2C/2D NMDAR antagonist (K_i values are 9 nM and 7 nM at GluN2C and GluN2D respectively). PPDA derivative. UBP1700 is one of the most potent GluN2 antagonists reported to date which shows ~50 to 60 fold selectivity for GluN2C/2D over GluN2A and ~40 to 50 fold selectivity for GluN2C/2D over GluN2B subunits. UBP1700 displays similar selectivity for GluN2C/2D as QNZ46 and DQP-1105 but has higher potency, thus is likely to inhibit receptors more effectively than these compounds where Glu2D-containing NMDARs are located (e.g. peri- and extrasynaptic spaces).

Soluble in DMSO (100 mM), in water with 1eq NaOH (50 mM) and in basic aqueous buffer (50 mM)

3-{8-[(E)-2-carboxyethenyl]naphthoyl}piperazine-2,3-dicarboxylic acid