Highly potent and selective GluN2C/2D NMDAR antagonist (Ki values are 9 nM and 7 nM at GluN2C and GluN2D respectively). PPDA derivative. UBP1700 is one of the most potent GluN2 antagonists reported to date which shows ~50 to 60 fold selectivity for GluN2C/2D over GluN2A and ~40 to 50 fold selectivity for GluN2C/2D over GluN2B subunits. UBP1700 displays similar selectivity for GluN2C/2D as QNZ46 and DQP-1105 but has higher potency, thus is likely to inhibit receptors more effectively than these compounds where Glu2D-containing NMDARs are located (e.g. peri- and extrasynaptic spaces).
Solubility & Handling
Soluble in DMSO (100 mM), in water with 1eq NaOH (50 mM) and in basic aqueous buffer (50 mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use