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Histone deacetylase (HDAC)

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Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

Items 11-20 of 38

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  1. Anti-GFP antibody ValidAb™ (HB6381)

    Description:

    Monoclonal antibody (IgM) to GFP - green coloured fluorescent protein widely used as a tag in molecular biology. Part of the ValidAb™ range of highly validated, data-rich antibodies. 

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Species Independent
    Figure 1. Specific HB6381 staining only in pEGFP-C2 transfected HEK293 cells.
    Pack:
    25μg
    Price:
    $140
    Qty:
    Pack:
    100μg
    Price:
    $311
    Qty:
    Supporting Docs Add to Favorites

  2. Anti-GFP antibody ValidAb™ (HB8365)

    Description:

    Antibody to GFP - green coloured fluorescent protein widely used as a tag in molecular biology. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Chicken
    Clonality: Polyclonal
    Reactivity Tested: Species Independent
    Figure 1. pEGFP-C2 transfected HEK293T cells showing co-localised staining of EGFP and HB8365.
    Pack:
    25μg
    Price:
    $140
    Qty:
    Pack:
    100μg
    Price:
    $311
    Qty:
    Supporting Docs Add to Favorites

  3. Anti-GST tag antibody ValidAbTM (HB9897)

    Description:

    Antibody to the GST tag - widely used as a protein tag in molecular biology. Part of the ValidAb™ range of highly validated, data-rich antibodies. 

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Species Independent
    Figure 1. Expression and purification of a GST-fusion protein monitored using HB9897.
    Pack:
    25μg
    Price:
    $141
    Qty:
    Pack:
    100μg
    Price:
    $315
    Qty:
    Supporting Docs Add to Favorites

  4. Anti-Histone H3 antibody ValidAb™ (HB6980)

    Description:

    Antibody to Histone H3 - Histone protein used as a loading control for western blotting. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Rabbit
    Clonality: Polyclonal
    Reactivity Tested: Mouse, Rat
    Figure 1. Histone H3 expression in various tissue lysates and preparations.
    Pack:
    25μL
    Price:
    $196
    Qty:
    Pack:
    100μL
    Price:
    $438
    Qty:
    Supporting Docs Add to Favorites

  5. Anti-HSP60 antibody ValidAb™ (HB7863)

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    Description:

    Antibody to HSP60 - loading control and mitochondrial marker for immunohistochemistry and immunocytochemistry. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Mouse, Rat, Human
    Figure 1. HSP60 staining with HB7863 reveals the dense mitochondria in cultured rat neurones.
    Pack:
    25μg
    Price:
    $155
    Qty:
    Pack:
    100μg
    Price:
    $352
    Qty:
    Supporting Docs Add to Favorites

  6. Anti-Ki-67 antibody ValidAbTM (HB7052)

    Description:

    Antibody to Ki-67 - a widely used marker of proliferating cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Human
    Figure 1. Ki-67 expression in proliferating HEK293T cells
    Pack:
    25μg
    Price:
    $139
    Qty:
    Pack:
    100μg
    Price:
    $310
    Qty:
    Supporting Docs Add to Favorites

  7. Anti-MAP2 antibody ValidAbTM (HB9587)

    Description:

    Antibody to MAP2 - cytoskeletal protein used as a neuronal marker. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Mouse, Rat
    Figure 1. MAP2 expression in cultured rat neurones visualised using HB9587.
    Pack:
    25μg
    Price:
    $136
    Qty:
    Pack:
    100μg
    Price:
    $311
    Qty:
    Supporting Docs Add to Favorites

  8. Anti-mCherry Antibody ValidAb™ (HB6512)

    Description:

    Antibody to mCherry - red coloured fluorescent protein widely used as a tag in molecular biology

    Host: Rabbit
    Clonality: Polyclonal
    Reactivity Tested: Species Independent
    Figure 1. pmCherry-C3 transfected HEK293 cells showing co-localised staining of mCherry and HB6512.
    Pack:
    25μg
    Price:
    $174
    Qty:
    Pack:
    100μg
    Price:
    $388
    Qty:
    Supporting Docs Add to Favorites

  9. Anti-Myelin Basic Protein (MBP) Antibody ValidAb™ (HB8014)

    Description:

    Antibody to myelin basic protein (MBP) - marker for oligodendrocytes and Schwann cells. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Rat, Mouse (no staining)
    MBP staining in the rat cerebellum
    Pack:
    25μg
    Price:
    $140
    Qty:
    Pack:
    100μg
    Price:
    $311
    Qty:
    Supporting Docs Add to Favorites

  10. Anti-NeuN antibody ValidAb™ (HB6429)

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    Description:

    Antibody to NeuN - marker for mature neurones expressed in the nucleus. Part of the ValidAb™ range of highly validated, data-rich antibodies.

    Host: Mouse
    Clonality: Monoclonal
    Reactivity Tested: Mouse, Rat
    Anti-NeuN antibody ValidAb™
    Pack:
    25μg
    Price:
    $163
    Qty:
    Pack:
    100μg
    Price:
    $366
    Qty:
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  1. Buffer
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Applications
  1. Antineoplastic Agent
  2. Cell Culture
  3. ELISA
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  5. fluorescence imaging
  6. ICC
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Host
  1. Mouse
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Conjugate
  1. Horseradish peroxidase (HRP)
Target
  1. GluN1
  2. GFAP
  3. GAPDH
  4. NeuN
  5. mCherry
  6. Neurofilament L
  7. Beta III tubulin
  8. HSP60
  9. Neurofilament M
  10. GFP
  11. MAP2
  12. Tyrosine hydroxylase
  13. β-tubulin
  14. Myelin basic protein
  15. GAT1
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  17. Mouse IgG H&L
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  19. GST tag
  20. VGAT
  21. Calretinin
  22. Histone H3
  23. Ki-67
  24. Chicken IgY H&L