Stem cells
Stem cells are unspecialized cells that are capable of self-renewal through mitotic cell division. They may be induced to form more specialized cells by a process termed cellular differentiation.The main types of stems cells are embryonic stem cells (ESCs) found in blastocysts; adult (or somatic) stem cells, found in adult tissues, induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). Small molecule pharmacological tools can be used to manipulate signalling pathways during the in vitro culture of stem cells. These tools can be used to target signaling pathways that control cell proliferation and differentiation. Researchers can save up to 50% on stem cell research tools from Hello Bio - they are around half the price of other suppliers.
View products: Differentiation | Organoids | Proliferation/Self-renewal | Reprogramming | Stem Cell Signaling View resources: Stem Cell Research Tools & Mini-Reviews
MK-2206 dihydrochloride (HB5934)
Description:Highly selective, pan-Akt inhibitor. Autophagy and apoptosis inducer. Orally bioavailable.
Purity:>98%
PD 0325901 (HB2240)
Description:Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Purity:>98%
Pertussis Toxin (HB4729)
Description:Catalyzes ADP-ribosylation of the G proteins Gαi, Gαo and Gαt
Purity:>98%
Rapamycin (HB2779)
Description:mTOR inhibitor and potent immunosuppressant. Also used in inducible gene editing methods (e.g. CRISPR/Cas9) and promotes hPSC differentiation.
Purity:>98%
SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%