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Pertussis Toxin

Technical documents: CoA Datasheet

Product overview

Name Pertussis Toxin
Alternative names PTX | PT | Islet-activating protein | Holotoxin
Purity >98%
Description Catalyzes ADP-ribosylation of the G proteins Gαi, Gαo and Gαt
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Biological Data

Biological description

Toxin produced by Bordetella pertussis . Catalyzes ADP-ribosylation of the α subunits of the heterotrimeric Gi/o proteins; Gαi, Gαo and Gαt . Blocks receptor coupling and activation by preventing G protein heterotrimers from interacting with receptors.


This product is not activated. Cells will activate pertussis toxin in an intact system however activation is required in a cell free system. Incubation with high concentrations of dithiothreitol (DTT) can achieve activation, see Kaslow, et al. (1987) for suggested conditions.


Solubility & Handling

Storage instructions +4°C for lyophilised or resuspended (do not freeze)

Use solutions within 1 month, long term storage is not recommended.

Before use the suspension should be gently mixed (not vortexed) to make the suspension uniform. Do not sterile filter.

Pertussis toxin can be inactivated by boiling for 30mins

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
CAS Number 70323-44-3
Source B. pertussis
Appearance Lyophilised
Formulation Contains 0.05M sodium phosphate and 0.5M sodium chloride at pH 7.2.

References for Pertussis Toxin

References are publications that support the biological activity of the product
  • G(i/o) protein-dependent and -independent actions of Pertussis Toxin (PTX).

    Mangmool and Kurose (2011) Toxins (Basel) 3(7) : 884-99
  • Structure-activity analysis of the activation of pertussis toxin.

    Kaslow et al (1987) Biochemistry 26(1) : 123-7
  • Subunit structure of islet-activating protein, pertussis toxin, in conformity with the A-B model.

    Tamura et al (1982) Biochemistry 21(22) : 5516-22.

3 Item(s)

These publications cite the use of Pertussis Toxin purchased from Hello Bio:
  • Differential activation of G protein-mediated signaling by synthetic cannabinoid receptor agonists

    Sachdev S et al (2020) Pharmacol Res Perspect 8(2) : e00566
    PubMedID: 32101383
  • Cannabichromene is a cannabinoid CB2 receptor agonist

    Udoh et al (2018) bioRxiv doi: : https://doi.org/10.1101/435057

2 Item(s)