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Images L-NAME product vial image | Hello Bio
L-NAME product vial image | Hello Bio Biological Data Biological description Non-selective nitric oxide synthase (NOS) inhibitor. Also inhibits cyclic GMP (IC50 = 3.1 μM). Methyl ester pro-drug of L-NNA. Induces hypertension.
Solubility & Handling Solubility overview Soluble in water (100mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name Nomega-Nitro-L-arginine methyl ester hydrochloride
Chemical structure
Molecular Formula C7 H15 N5 O4 .HCl
PubChem identifier 135193
SMILES COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl
InChi InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChiKey QBNXAGZYLSRPJK-JEDNCBNOSA-N
References for L-NAME References are publications that support the biological activity of the product
L-NAME in the cardiovascular system - nitric oxide synthase activator? Kopincová J et al (2012) Pharmacol Rep 64(3) : 511-20. Nitric oxide synthases: structure, function and inhibition. Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.
Publications
These publications cite the use of L-NAME purchased from Hello Bio:
Vascular remodelling in a mouse model of heart failure with preserved ejection fraction. Sanhueza-Olivares F et al (2025) The Journal of physiology Cerebellar interneurons control fear memory consolidation via learning-induced HCN plasticity. Carzoli KL et al (2023) Cell reports 42 : 113057
Non-selective NOS inhibitor. Induces hypertension.
![L-NAME [51298-62-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1352.png "L-NAME [51298-62-5]")
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