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Biological Data

Biological description Non-selective nitric oxide synthase (NOS) inhibitor. Also inhibits cyclic GMP (IC50 = 3.1 μM). Methyl ester pro-drug of L-NNA. Displays hypertensive properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name Nomega-Nitro-L-arginine methyl ester hydrochloride
Molecular Weight 269.69
Chemical structure L-NAME  [51298-62-5] Chemical Structure
Molecular Formula C7H15N5O4.HCl
CAS Number 51298-62-5
PubChem identifier 135193
SMILES COC(=O)[C@H](CCCN=C(N)N[N+](=O)[O-])N.Cl
InChi InChI=1S/C7H15N5O4.ClH/c1-16-6(13)5(8)3-2-4-10-7(9)11-12(14)15;/h5H,2-4,8H2,1H3,(H3,9,10,11);1H/t5-;/m0./s1
InChiKey QBNXAGZYLSRPJK-JEDNCBNOSA-N
MDL number MFCD00039052

References for L-NAME

References are publications that support the biological activity of the product
  • L-NAME in the cardiovascular system - nitric oxide synthase activator?

    Kopincová J et al (2012) Pharmacol Rep 64(3) : 511-20.
  • Nitric oxide synthases: structure, function and inhibition.

    Alderton WK et al (2001) Biochem J 357(Pt 3) : 593-615.
  • Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo.

    Rees DD et al (1990) Br J Pharmacol 101(3) : 746-52.