Stem cells
Stem cells are unspecialized cells that are capable of self-renewal through mitotic cell division. They may be induced to form more specialized cells by a process termed cellular differentiation.The main types of stems cells are embryonic stem cells (ESCs) found in blastocysts; adult (or somatic) stem cells, found in adult tissues, induced pluripotent stem cells (iPSCs) and cancer stem cells (CSCs). Small molecule pharmacological tools can be used to manipulate signalling pathways during the in vitro culture of stem cells. These tools can be used to target signaling pathways that control cell proliferation and differentiation. Researchers can save up to 50% on stem cell research tools from Hello Bio - they are around half the price of other suppliers.
View products: Differentiation | Organoids | Proliferation/Self-renewal | Reprogramming | Stem Cell Signaling View resources: Stem Cell Research Tools & Mini-Reviews
A83-01 (HB3218)
Description:Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.
Purity:>98%
Calphostin C (HB0160)
Description:Potent, selective PKC inhibitor. Also antagonizes the Tcf/β-catenin complex
Purity:>95%
CHIR 99021 (HB1261)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Purity:>98%
DAPT (HB3345)
Description:γ-secretase inhibitor and classical notch inhibitor. Induces neuronal differentiation. 3D Growth matrix component and used in cerebral organoid differentiation media.
Purity:>98%
Dorsomorphin dihydrochloride (HB2800)
Description:Potent, selective AMPK inhibitor. Promotes neural hPSCs differentiation and promotes cardiomyocyte differentiation in mESCs.
Purity:>98%
EHNA hydrochloride (HB3540)
Description:Potent adenosine deaminase and PDE2 inhibitor. Supresses spontaneous hESC differentiation. Also maintains pluripotency of hESCs in the absence of exogenous cytokines.
Purity:>98%
Fluoxetine hydrochloride (HB1600)
Description:Selective 5-HT uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%
IBMX (HB3000)
Description:Non-selective, competitive cAMP and cGMP PDE inhibitor. Facilitates neural progenitor cell differentiation.
Purity:>98%
ICG 001 (HB0331)
Description:Selective, competitive inhibitor of β-catenin/CBP interaction
Purity:>98%