Fluoxetine hydrochloride
(HB1600)
Product overview
| Name | Fluoxetine hydrochloride |
| Description | Selective 5-HT uptake inhibitor. Affects differentiation of NSCs. |
| Purity | >98% |
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Biological Data
| Biological description | Potent, selective 5-HT reuptake inhibitor (Ki = 2 nM at rSERT). Also acts at other receptors and channels. Shows ~150-900 fold selectivity over 5-HT1a,-2A, muscarinic, α1, α2-adrenoceptors and H1 receptors. Also affects differentiation of neural stem cells (NSCs). Shows antidepressant effects. Active in vivo. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in water (10mM) and in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride |
| Molecular Weight | 345.78 |
| Chemical structure | ![Fluoxetine hydrochloride [56296-78-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1600.png "Fluoxetine hydrochloride [56296-78-7]") |
| Molecular Formula | C17H18F3NO.HCl |
| CAS Number | 56296-78-7 |
| PubChem identifier | 62857 |
| SMILES | CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl |
| InChi | InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H |
| InChiKey | GIYXAJPCNFJEHY-UHFFFAOYSA-N |
| MDL number | MFCD00214288 |
References for Fluoxetine hydrochloride
References are publications that support the biological activity of the product
-
Fluoxetine, a selective inhibitor of serotonin uptake.
Fuller RW et al (1991) Med Res Rev 11(1) : 17-34. -
Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.
Wong DT et al (1990) Acta Pharm Nord 2(3) : 171-80. -
Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.
Benfield P et al (1986) Drugs 32(6) : 481-508.
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