Product overview

Name Fluoxetine hydrochloride
Description Selective 5-HT uptake inhibitor. Affects differentiation of NSCs.
Purity >98%
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Biological Data

Biological description Potent, selective 5-HT reuptake inhibitor (Ki = 2 nM at rSERT). Also acts at other receptors and channels. Shows ~150-900 fold selectivity over 5-HT1a,-2A, muscarinic, α1, α2-adrenoceptors and H1 receptors. Also affects differentiation of neural stem cells (NSCs). Shows antidepressant effects. Active in vivo.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (10mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name N-Methyl-3-[(4-trifluoromethyl)phenoxy]-3-phenylpropylamine hydrochloride
Molecular Weight 345.78
Chemical structure Fluoxetine hydrochloride  [56296-78-7] Chemical Structure
Molecular Formula C17H18F3NO.HCl
CAS Number 56296-78-7
PubChem identifier 62857
SMILES CNCCC(C1=CC=CC=C1)OC2=CC=C(C=C2)C(F)(F)F.Cl
InChi InChI=1S/C17H18F3NO.ClH/c1-21-12-11-16(13-5-3-2-4-6-13)22-15-9-7-14(8-10-15)17(18,19)20;/h2-10,16,21H,11-12H2,1H3;1H
InChiKey GIYXAJPCNFJEHY-UHFFFAOYSA-N
MDL number MFCD00214288

References for Fluoxetine hydrochloride

References are publications that support the biological activity of the product
  • Fluoxetine, a selective inhibitor of serotonin uptake.

    Fuller RW et al (1991) Med Res Rev 11(1) : 17-34.
  • Fluoxetine and its two enantiomers as selective serotonin uptake inhibitors.

    Wong DT et al (1990) Acta Pharm Nord 2(3) : 171-80.
  • Fluoxetine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depressive illness.

    Benfield P et al (1986) Drugs 32(6) : 481-508.

3 Item(s)