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Images
Calphostin C product vial image | Hello Bio
Calphostin C product vial image | Hello Bio
Biological Data
| Biological description | Potent and selective photo-activated PKC inhibitor (IC50 = 50 nM). Antagonizes the Tcf/β-catenin complex. Inhibits glioma tumour cell proliferation and protects the myocardium against ischemic injury. |
Solubility & Handling
| Storage instructions | +4°C (desiccate) |
| Solubility overview | Soluble in DMSO or ethanol |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester |
| Chemical structure | ![Calphostin C [121263-19-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Calphostin C [121263-19-2]") |
| Molecular Formula | C44H38O14 |
| SMILES | CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7 |
| InChiKey | YYMCVDNIIFNDJK-BEQMOXJMSA-N |
References for Calphostin C
References are publications that support the biological activity of the product
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In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.
Matsuzaki S et al (2013) PLoS One 8(4) : e61690. -
The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.
Pollack IF et al (1997) J Neurooncol 31(3) : 255-66. -
The role of protein kinase in C ischemic/reperfused preconditioned isolated rat hearts.
Tosaki A et al (1996) J Cardiovasc Pharmacol 28(5) : 723-31.
Potent, selective PKC inhibitor. Also antagonizes the Tcf/β-catenin complex
![Calphostin C [121263-19-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0160.png "Calphostin C [121263-19-2]")
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