Product overview

Name Calphostin C
Description Potent, selective PKC inhibitor. Also antagonizes the Tcf/β-catenin complex
Alternative names UCN 1028C|PKF 115-584
Purity >95%
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Biological Data

Biological description Potent and selective photo-activated PKC inhibitor (IC50 = 50 nM). Antagonizes the Tcf/β-catenin complex. Inhibits glioma tumour cell proliferation and protects the myocardium against ischemic injury.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO or ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Molecular Weight 790.76
Chemical structure Calphostin C  [121263-19-2] Chemical Structure
Molecular Formula C44H38O14
CAS Number 121263-19-2
PubChem identifier 2533
SMILES CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7
InChiKey YYMCVDNIIFNDJK-BEQMOXJMSA-N

References for Calphostin C

References are publications that support the biological activity of the product
  • In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.

    Matsuzaki S et al (2013) PLoS One 8(4) : e61690.
  • The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.

    Pollack IF et al (1997) J Neurooncol 31(3) : 255-66.
  • The role of protein kinase in C ischemic/reperfused preconditioned isolated rat hearts.

    Tosaki A et al (1996) J Cardiovasc Pharmacol 28(5) : 723-31.