Product overview

Name Calphostin C
Alternative names UCN 1028C|PKF 115-584
Purity >95%
Description Potent, selective PKC inhibitor. Also antagonizes the Tcf/β-catenin complex
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Biological Data

Biological description Potent and selective photo-activated PKC inhibitor (IC50 = 50 nM). Antagonizes the Tcf/β-catenin complex. Inhibits glioma tumour cell proliferation and protects the myocardium against ischemic injury.

Solubility & Handling

Storage instructions +4°C (desiccate)
Solubility overview Soluble in DMSO or ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name (1R)-2-[12-[(2R)-2-(Benzoyloxy)propyl]-3,10-dihydro-4,9-dihydroxy-2,6,7,11-tetramethoxy-3,10-dioxo-1-perylenyl]-1-methylethylcarbonic acid 4-hydroxyphenyl ester
Molecular Weight 790.76
Chemical structure Calphostin C  [121263-19-2] Chemical Structure
Molecular Formula C44H38O14
CAS Number 121263-19-2
PubChem identifier 2533
SMILES CC(CC1=C(C(=C2C(=O)C=C(C3=C4C(=CC(=O)C5=C(C(=C(C(=C45)C1=C32)CC(C)OC(=O)OC6=CC=C(C=C6)O)OC)O)OC)OC)O)OC)OC(=O)C7=CC=CC=C7

References for Calphostin C

References are publications that support the biological activity of the product
  • In vitro effects of a small-molecule antagonist of the Tcf/β-catenin complex on endometrial and endometriotic cells of patients with endometriosis.

    Matsuzaki S et al (2013) PLoS One 8(4) : e61690.
  • The effect of calphostin C, a potent photodependent protein kinase C inhibitor, on the proliferation of glioma cells in vitro.

    Pollack IF et al (1997) J Neurooncol 31(3) : 255-66.
  • The role of protein kinase in C ischemic/reperfused preconditioned isolated rat hearts.

    Tosaki A et al (1996) J Cardiovasc Pharmacol 28(5) : 723-31.

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