Product overview

Name FH 535
Purity >99%
Description Wnt/β-catenin inhibitor and PPARγ/δ antagonist.
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Biological Data

Biological description Wnt/β-catenin inhibitor and PPARγ/δ antagonist. Reduces NO production. Shows antiproliferative and anti-cancer actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (75mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide
Molecular Weight 361.2
Chemical structure FH 535  [108409-83-2] Chemical Structure
Molecular Formula C13H10Cl2N2O4S
CAS Number 108409-83-2
PubChem identifier 3463933
SMILES ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1

References for FH 535

References are publications that support the biological activity of the product
  • FH535 inhibits the proliferation of HepG2 cells via downregulation of the Wnt/β-catenin signaling pathway.

    Liu J et al (2014) Mol Med Rep 9(4) : 1289-92.
  • Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535.

    Gedaly R et al (2014) PLoS One 9(6) : e99272.
  • A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.

    Handeli S et al (2008) Mol Cancer Ther 7(3) : 521-9.

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