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Biological Data
| Biological description | Wnt/β-catenin inhibitor and PPARγ/δ antagonist. Reduces NO production. Shows antiproliferative and anti-cancer actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (75mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2,5-Dichloro-N-(2-methyl-4-nitrophenyl)benzenesulfonamide |
| Chemical structure | ![FH 535 [108409-83-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "FH 535 [108409-83-2]") |
| Molecular Formula | C13H10Cl2N2O4S |
| PubChem identifier | 3463933 |
| SMILES | ClC1=CC(S(NC2=C(C)C=C([N+]([O-])=O)C=C2)(=O)=O)=C(Cl)C=C1 |
| InChiKey | AXNUEXXEQGQWPA-UHFFFAOYSA-N |
References for FH 535
References are publications that support the biological activity of the product
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FH535 inhibits the proliferation of HepG2 cells via downregulation of the Wnt/β-catenin signaling pathway.
Liu J et al (2014) Mol Med Rep 9(4) : 1289-92. -
Targeting the Wnt/β-catenin signaling pathway in liver cancer stem cells and hepatocellular carcinoma cell lines with FH535.
Gedaly R et al (2014) PLoS One 9(6) : e99272. -
A small-molecule inhibitor of Tcf/beta-catenin signaling down-regulates PPARgamma and PPARdelta activities.
Handeli S et al (2008) Mol Cancer Ther 7(3) : 521-9.
Wnt/β-catenin inhibitor and PPARγ/δ antagonist.
![FH 535 [108409-83-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0288.png "FH 535 [108409-83-2]")
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