Product overview
| Name | ICG 001 |
| Description | Selective, competitive inhibitor of β-catenin/CBP interaction |
| Purity | >98% |
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Biological Data
| Biological description | Selective and competitive inhibitor of β-catenin/ CREB-binding protein (CBP) interaction (IC50 = 3.0 µM). Exhibits little activity on β-catenin/p300. Also inhibits TGF-β1 induced α-SMA induction. Displays cardioprotective and apoptosis inducing properties. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (6S,9aS)-Hexahydro-6-[(4-hydroxyphenyl)methyl]-8-(1-naphthalenylmethyl)-4,7-dioxo-N-(phenylmethyl)-2H-pyrazino[1,2-a]pyrimidine-1(6H)-carboxamide |
| Molecular Weight | 548.63 |
| Chemical structure | ![ICG 001 [780757-88-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0331.png "ICG 001 [780757-88-2]") |
| Molecular Formula | C33H32N4O4 |
| CAS Number | 780757-88-2 |
| PubChem identifier | 11238147 |
| SMILES | O=C1CCN(C(NCC5=CC=CC=C5)=O)[C@]2([H])N1[C@@H](CC6=CC=C(O)C=C6)C(N(CC3=C(C=CC=C4)C4=CC=C3)C2)=O |
| InChiKey | HQWTUOLCGKIECB-XZWHSSHBSA-N |
References for ICG 001
References are publications that support the biological activity of the product
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The small molecule Wnt signaling modulator ICG-001 improves contractile function in chronically infarcted rat myocardium.
Sasaki T et al (2013) PLoS One 8(9) : e75010. -
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
Zhou B et al (2012) J Biol Chem 287(10) : 7026-38. -
ICG-001, a novel small molecule regulator of TCF/beta-catenin transcription.
Eguchi M et al (2005) Med Chem 1(5) : 467-72. -
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected].
Emami KH et al (2004) Proc Natl Acad Sci U S A 101(34) : 12682-7.
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