Selective and competitive inhibitor of β-catenin/ CREB-binding protein (CBP) interaction (IC50 = 3.0 µM). Exhibits little activity on β-catenin/p300. Also inhibits TGF-β1 induced α-SMA induction. Displays cardioprotective and apoptosis inducing properties.
Solubility & Handling
Soluble in DMSO (100mM) or ethanol (50mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP)
Zhou B et al (2012) J Biol Chem 287(10) : 7026-38.