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Designer receptors exclusively activated by designer drugs (DREADDs) are genetically engineered GPCRs that are activated by physiologically inert synthetic small molecules (designer drugs) but not their endogenous ligand. Read our DREADDs mini-review or for practical advice on using these ligands in the lab see Stability of Water-Soluble DREADD Ligands in Solution: A Technical Review and Clozapine N-Oxide (freebase) - a technical review on stability, solubility and use in the lab).
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Aphidicolin (HB3690)
Description:DNA replication inhibitor. Useful for cell synchronization
Purity:>98%
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AY 9944 dihydrochloride (HB3543)
Description:Hedgehog signaling inhibitor. Δ,7-dehydrocholesterol reductase inhibitor.
Purity:>99%
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5-aza-2'-deoxycytidine (Decitabine) (HB1356)
Description:DNA methyltransferase inhibitor
Purity:>99%
