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5-aza-2'-deoxycytidine (Decitabine)

(HB1356)
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Product overview

Name 5-aza-2'-deoxycytidine (Decitabine)
Alternative names 5-Aza-CdR, 5-Aza-dC, 5-Deoxy-2'-azacytidine; Decitabine; ZdCyd; DAC
Purity >99%
Description DNA methyltransferase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description DNA methyltransferase inhibitor. Prevents DNA methylation after incorporation into DNA. Enhances histone deacetylase (HDAC) inhibitor-induced apoptosis. Shows actions against atherosclerosis and cancer.

Solubility & Handling

Solubility overview Soluble in water (50mM) or DMSO (50mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-Amino-1-(2-deoxy-β-D-erythro-pento furanosyl)-1,3,5-triazin-2(1H)-one
Molecular Weight 228.21
Molecular Formula C8H12N4O4
CAS Number 2353-33-5
PubChem identifier 451668
SMILES O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(N)=NC2=O)C1
InChiKey XAUDJQYHKZQPEU-KVQBGUIXSA-N

References for 5-aza-2'-deoxycytidine (Decitabine)

References are publications that support the biological activity of the product

  • Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

    Cao Q et al (2014) Endocrinology 155(12) : 4925-38.
    Read more (PubMedID: 25251587)

  • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

    Christman JK (2002) Oncogene 21(35) : 5483-95.
    Read more (PubMedID: 12154409)

  • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

    Zhu WG et al (2001) Cancer Res 61(4) : 1327-33.
    Read more (PubMedID: 11245429)

  • Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

    Eggert A et al (2001) Cancer Res 61(4) : 1314-9.
    Read more (PubMedID: 11245427)

4 Item(s)

Grouped product items
Order: HB1356
Pack PriceQty
10mg
$121
50mg
$480
DNA methyltransferase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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