5-aza-2'-deoxycytidine (Decitabine)

Name: 5-aza-2'-deoxycytidine (Decitabine)
Brand: Hello Bio
SKU: HB1356
Price: 116 USD
Availability: InStock

(HB1356)

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Technical documents: SDS Datasheet

Product overview

Name

5-aza-2'-deoxycytidine (Decitabine)

Alternative names

5-Aza-CdR, 5-Aza-dC, 5-Deoxy-2'-azacytidine; Decitabine; ZdCyd; DAC

Purity

>99%

Description

DNA methyltransferase inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Biological Data

Biological description

DNA methyltransferase inhibitor. Prevents DNA methylation after incorporation into DNA. Enhances histone deacetylase (HDAC) inhibitor-induced apoptosis. Shows actions against atherosclerosis and cancer.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in water (50mM) or DMSO (50mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

4-Amino-1-(2-deoxy-β-D-erythro-pento furanosyl)-1,3,5-triazin-2(1H)-one

Molecular Weight

228.21

Molecular Formula

C₈H₁₂N₄O₄

CAS Number

2353-33-5

PubChem identifier

451668

SMILES

O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(N)=NC2=O)C1

InChiKey

XAUDJQYHKZQPEU-KVQBGUIXSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for 5-aza-2'-deoxycytidine (Decitabine)

References are publications that support the biological activity of the product

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.
Cao Q et al (2014) Endocrinology 155(12) : 4925-38.
Read more (PubMedID: 25251587)
5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.
Christman JK (2002) Oncogene 21(35) : 5483-95.
Read more (PubMedID: 12154409)
DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.
Zhu WG et al (2001) Cancer Res 61(4) : 1327-33.
Read more (PubMedID: 11245429)
Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
Eggert A et al (2001) Cancer Res 61(4) : 1314-9.
Read more (PubMedID: 11245427)

DNA methyltransferase inhibitor

Order: HB1356
Pack	Price	Qty
10mg	$116
50mg	$460

5-aza-2'-deoxycytidine (Decitabine)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for 5-aza-2'-deoxycytidine (Decitabine)

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

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Tell us about your publication!

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New Products in this Area

5-aza-2'-deoxycytidine (Decitabine)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for 5-aza-2'-deoxycytidine (Decitabine)

Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

About you

Tell us about your publication!

Captcha

About you

How can we help you?

New Products in this Area