Product overview

Name 5-aza-2'-deoxycytidine (Decitabine)
Description DNA methyltransferase inhibitor
Alternative names 5-Aza-CdR, 5-Aza-dC, 5-Deoxy-2'-azacytidine; Decitabine; ZdCyd; DAC
Purity >99%
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Biological Data

Biological description DNA methyltransferase inhibitor. Prevents DNA methylation after incorporation into DNA. Enhances histone deacetylase (HDAC) inhibitor-induced apoptosis. Shows actions against atherosclerosis and cancer.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water (50mM) or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-Amino-1-(2-deoxy-β-D-erythro-pento furanosyl)-1,3,5-triazin-2(1H)-one
Molecular Weight 228.21
Molecular Formula C8H12N4O4
CAS Number 2353-33-5
PubChem identifier 451668
SMILES O[C@@H]1[C@@H](CO)O[C@@H](N2C=NC(N)=NC2=O)C1
InChiKey XAUDJQYHKZQPEU-KVQBGUIXSA-N

References for 5-aza-2'-deoxycytidine (Decitabine)

References are publications that support the biological activity of the product
  • Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation.

    Cao Q et al (2014) Endocrinology 155(12) : 4925-38.
  • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: mechanistic studies and their implications for cancer therapy.

    Christman JK (2002) Oncogene 21(35) : 5483-95.
  • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors.

    Zhu WG et al (2001) Cancer Res 61(4) : 1327-33.
  • Resistance to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.

    Eggert A et al (2001) Cancer Res 61(4) : 1314-9.