Product overview

Name Ascomycin
Alternative names FK 520, FR 900520
Purity >98%
Description Calcineurin phosphatase inhibitor
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Biological Data

Biological description Calcineurin phosphatase inhibitor that binds to FK 506-binding protein 12 (FKBP12) (IC50 = 49 nM). Also suppresses T-cells (IC50 = 3.9 nM). Displays neurogenerative, neuroprotective and anticonvulsant properties.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (50mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (3S,4R,5S,8R,9E,12S,14S,15R,16S,18R ,19R,26aS)-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E )-2-[(1R,3R,4R)-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth yl-15,19-epoxy-3H-pyrido[2,1-c][1,4]oxaazacyclotricosine-1,7,20,21(4H,23H)tetrone
Molecular Weight 792.01
Chemical structure Ascomycin  [104987-12-4] Chemical Structure
Molecular Formula C43H69NO12
CAS Number 104987-12-4
PubChem identifier 5282071
SMILES O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1

References for Ascomycin

References are publications that support the biological activity of the product
  • Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants.

    Sierra-Paredes G et al (2008) CNS Neurosci Ther 14(1) : 36-46.
  • Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus.

    Vázquez-López A et al (2006) Pharmacol Biochem Behav 84(3) : 511-6.
  • Genetically engineered analogs of ascomycin for nerve regeneration.

    Revill WP et al (2002) J Pharmacol Exp Ther 302(3) : 1278-85.

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