The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Images Ascomycin product vial image | Hello Bio
Ascomycin product vial image | Hello Bio Biological Data Biological description Calcineurin phosphatase inhibitor that binds to FK 506-binding protein 12 (FKBP12) (IC50 = 49 nM). Also suppresses T-cells (IC50 = 3.9 nM). Displays neurogenerative, neuroprotective and anticonvulsant properties.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (50mM) or ethanol (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3S ,4R ,5S ,8R ,9E ,12S ,14S ,15R ,16S ,18R ,19R ,26aS )-8-Ethyl-5,6,8,11,12,13,14,15,16,17,18,1 9,24,25,26,26a-hexadecahydro-5,19-dihydroxy-3-[(1E )-2-[(1R ,3R ,4R )-4-hydroxy-3-methoxycyclohexyl]-1-methylethenyl]-14,16-dimethoxy-4,10,12,18-tetrameth yl-15,19-epoxy-3H -pyrido[2,1-c ][1,4]oxaazacyclotricosine-1,7,20,21(4H ,23H )tetrone
Chemical structure
Molecular Formula C43 H69 NO12
PubChem identifier 5282071
SMILES O[C@H]1[C@H](OC)C[C@H](/C=C(C)/[C@@H](O4)[C@H](C)[C@@H](O)CC([C@H](CC)/C=C(C)/C[C@H](C)C[C@H](OC)[C@@]2([H])O[C@](C(C(N3[C@@](C4=O)([H])CCCC3)=O)=O)(O)[C@H](C)C[C@@H]2OC)=O)CC1
InChiKey ZDQSOHOQTUFQEM-NURRSENYSA-N
References for Ascomycin References are publications that support the biological activity of the product
Ascomycin and FK506: pharmacology and therapeutic potential as anticonvulsants and neuroprotectants. Sierra-Paredes G et al (2008) CNS Neurosci Ther 14(1) : 36-46. Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus. Vázquez-López A et al (2006) Pharmacol Biochem Behav 84(3) : 511-6. Genetically engineered analogs of ascomycin for nerve regeneration. Revill WP et al (2002) J Pharmacol Exp Ther 302(3) : 1278-85.
Calcineurin phosphatase inhibitor
![Ascomycin [104987-12-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0123.png "Ascomycin [104987-12-4]")
Understanding purity and quality - a guide for life scientists