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Biological Data

Biological description Potent and selective GSK3 inhibitor (IC50 = 104 nM) which acts competitively. Exhibits little activity for cdk2 and cdk5 (IC50 values are >100 µM). Also inhibits tau phosphorylation (IC50 = 2.7 µM).

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (5mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea
Molecular Weight 308.31
Chemical structure AR-A 014418  [487021-52-3] Chemical Structure
Molecular Formula C12H12N4O4S
CAS Number 487021-52-3
PubChem identifier 448014
SMILES O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1
InChiKey YAEMHJKFIIIULI-UHFFFAOYSA-N

References for AR-A 014418

References are publications that support the biological activity of the product
  • AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.

    Yadav AK et al (2014) J Oncol 2014 : 695325
  • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.

    Bhat R et al (2003) J Biol Chem 278(46) : 45937-45.