Product overview
| Name | AR-A 014418 |
| Description | Potent, selective GSK3 inhibitor |
| Purity | >99% |
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Biological Data
| Biological description | Potent and selective GSK3 inhibitor (IC50 = 104 nM) which acts competitively. Exhibits little activity for cdk2 and cdk5 (IC50 values are >100 µM). Also inhibits tau phosphorylation (IC50 = 2.7 µM). |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (5mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[(4-Methoxyphenyl)methyl]-N'-(5-nitro-2-thiazolyl)urea |
| Molecular Weight | 308.31 |
| Chemical structure | ![AR-A 014418 [487021-52-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1258.png "AR-A 014418 [487021-52-3]") |
| Molecular Formula | C12H12N4O4S |
| CAS Number | 487021-52-3 |
| PubChem identifier | 448014 |
| SMILES | O=C(NCC2=CC=C(OC)C=C2)NC1=NC=C([N+]([O-])=O)S1 |
| InChiKey | YAEMHJKFIIIULI-UHFFFAOYSA-N |
References for AR-A 014418
References are publications that support the biological activity of the product
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AR-A 014418 Used against GSK3beta Downregulates Expression of hnRNPA1 and SF2/ASF Splicing Factors.
Yadav AK et al (2014) J Oncol 2014 : 695325 -
Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418.
Bhat R et al (2003) J Biol Chem 278(46) : 45937-45.
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