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Product overview

Name Apamin
Purity >80%
Description Potent, selective KCa2 channel subfamily inhibitor
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Biological Data

Biological description Potent, selective KCa2 channel subfamily inhibitor (IC50 values are 3.3 nM and 83 pM for hKCa2.1 and rKCa2.2 channels respectively). Found in the venom of Apis mellifera bee. Blood brain barrier permeable. Displays anti-inflammatory properties.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >80%
Molecular Weight 2027.34
Molecular Formula C79H131N31O24S4
CAS Number 24345-16-2
PubChem identifier 16133797
SMILES [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O

References for Apamin

References are publications that support the biological activity of the product
  • The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice.

    Kim SJ et al (2012) Evid Based Complement Alternat Med 2012 : 305454
  • Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.

    Strøbaek D et al (2000) Br J Pharmacol 129(5) : 991-9.
  • Behavioral effects of apamin, a selective inhibitor of the SK(Ca)-channel, in mice and rats.

    van der Staay FJ et al (1999) Neurosci Biobehav Rev 23(8) : 1087-110.
  • Apamin.

    Habermann E (1984) Pharmacol Ther 25(2) : 255-70.

4 Item(s)

These publications cite the use of Apamin purchased from Hello Bio:
  • Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons

    Lahiri and Bevan (2020) Neuron 106(2) : 277-290
    PubMedID: 32075716

1 Item