Product overview
| Name | Apamin |
| Purity | >80% |
| Description | Potent, selective KCa2 channel subfamily inhibitor |
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Biological Data
| Biological description | Potent, selective KCa2 channel subfamily inhibitor (IC50 values are 3.3 nM and 83 pM for hKCa2.1 and rKCa2.2 channels respectively). Found in the venom of Apis mellifera bee. Blood brain barrier permeable. Displays anti-inflammatory properties. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (1mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >80% |
| Molecular Weight | 2027.34 |
| Molecular Formula | C79H131N31O24S4 |
| CAS Number | 24345-16-2 |
| PubChem identifier | 16133797 |
| SMILES | [H]N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H]3CCCN3C(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)NC2=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC2=CNC=N2)C(N)=O)NC(=O)[C@H](CC(N)=O)NC1=O)[C@@H](C)O |
| InChiKey | YVIIHEKJCKCXOB-STYWVVQQSA-N |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for Apamin
References are publications that support the biological activity of the product
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The Protective Effect of Apamin on LPS/Fat-Induced Atherosclerotic Mice.
Kim SJ et al (2012) Evid Based Complement Alternat Med 2012 : 305454 -
Pharmacological characterization of small-conductance Ca(2+)-activated K(+) channels stably expressed in HEK 293 cells.
Strøbaek D et al (2000) Br J Pharmacol 129(5) : 991-9. -
Behavioral effects of apamin, a selective inhibitor of the SK(Ca)-channel, in mice and rats.
van der Staay FJ et al (1999) Neurosci Biobehav Rev 23(8) : 1087-110. -
Apamin.
Habermann E (1984) Pharmacol Ther 25(2) : 255-70.
Publications
These publications cite the use of Apamin purchased from Hello Bio:
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Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons
Lahiri and Bevan (2020) Neuron 106(2) : 277-290PubMedID: 32075716
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