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Biological Data
| Biological description | Potent histone deacetylase (HDAC) inhibitor (IC50 = 5 nM). Shows anti-protozoal, anti-angiogenic, anti-proliferative and anti-cancer actions. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (2mM) or ethanol (2mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Cyclo[(2S)-2-Amino-8-oxodecanoyl-1- methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidine carbonyl] |
| Chemical structure | ![Apicidin [183506-66-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Apicidin [183506-66-3]") |
| Molecular Formula | C34H49N5O6 |
| PubChem identifier | 44593387 |
| SMILES | CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2 |
| InChiKey | JWOGUUIOCYMBPV-VWIQTCEGSA-N |
References for Apicidin
References are publications that support the biological activity of the product
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Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.
Kim SH et al (2004) Biochem Biophys Res Commun 315(4) : 964-70. -
Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.
Han JW et al (2000) Cancer Res 60(21) : 6068-74. -
Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.
Darkin-Rattray SJ et al (1996) Proc Natl Acad Sci U S A 93(23) : 13143-7.
![Apicidin [183506-66-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1384.png "Apicidin [183506-66-3]")
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