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Biological Data Biological description Potent histone deacetylase (HDAC) inhibitor (IC50 = 5 nM). Shows anti-protozoal, anti-angiogenic, anti-proliferative and anti-cancer actions.
Solubility & Handling Solubility overview Soluble in DMSO (2mM) or ethanol (2mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name Cyclo[(2S )-2-Amino-8-oxodecanoyl-1- methoxy-L-tryptophyl-L-isoleucyl-(2R )-2-piperidine carbonyl]
Chemical structure
Molecular Formula C34 H49 N5 O6
PubChem identifier 44593387
SMILES CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2
InChiKey JWOGUUIOCYMBPV-VWIQTCEGSA-N
References for Apicidin References are publications that support the biological activity of the product
Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials. Kim SH et al (2004) Biochem Biophys Res Commun 315(4) : 964-70. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Han JW et al (2000) Cancer Res 60(21) : 6068-74. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Darkin-Rattray SJ et al (1996) Proc Natl Acad Sci U S A 93(23) : 13143-7.
![Apicidin [183506-66-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1384.png "Apicidin [183506-66-3]")
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