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Biological Data

Biological description Potent histone deacetylase (HDAC) inhibitor (IC50 = 5 nM). Shows anti-protozoal, anti-angiogenic, anti-proliferative and anti-cancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (2mM) or ethanol (2mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name Cyclo[(2S)-2-Amino-8-oxodecanoyl-1- methoxy-L-tryptophyl-L-isoleucyl-(2R)-2-piperidine carbonyl]
Molecular Weight 623.78
Chemical structure Apicidin  [183506-66-3] Chemical Structure
Molecular Formula C34H49N5O6
CAS Number 183506-66-3
PubChem identifier 44593387
SMILES CON2C1=CC=CC=C1C(C[C@@H](C(N[C@@H]([C@H](C)CC)C3=O)=O)NC([C@H](CCCCCC(CC)=O)NC([C@]4([H])N3CCCC4)=O)=O)=C2
InChiKey JWOGUUIOCYMBPV-VWIQTCEGSA-N

References for Apicidin

References are publications that support the biological activity of the product
  • Apicidin is a histone deacetylase inhibitor with anti-invasive and anti-angiogenic potentials.

    Kim SH et al (2004) Biochem Biophys Res Commun 315(4) : 964-70.
  • Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin.

    Han JW et al (2000) Cancer Res 60(21) : 6068-74.
  • Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase.

    Darkin-Rattray SJ et al (1996) Proc Natl Acad Sci U S A 93(23) : 13143-7.