Product overview
| Name | Arctigenin |
| Alternative names | (-)-Arctigenin |
| Purity | >98% |
| Description | Potent MAP kinase kinase (MKK/MEK) inhibitor |
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Biological Data
| Biological description | Potent MAP kinase kinase (MKK/MEK) inhibitor (IC50 = 1 nM for MKK1/MEK1). Antiviral, anti-cancer, antioxidant and anti-inflammatory compound. Inhibits iNOS expression by suppressing 1-κBα phosphorylation and nuclear translocation of p65 (IC50 = 10 nM). Shows neuroprotective actions. |
Solubility & Handling
| Solubility overview | Soluble in ethanol (25mM, gentle warming) or DMSO (100mM) |
| Storage instructions | -20°C (desiccate) |
| Storage of solutions | Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use. |
| Shipping Conditions | Stable for ambient temperature shipping. Follow storage instructions on receipt. |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Purity | >98% |
| Chemical name | (3R,4R)-4-[(3,4-Dimethoxyphenyl)methyl]dihydro-3-[(4-hydroxy-3-methoxyphenyl)methyl]-2(3H)-furanone |
| Molecular Weight | 372.42 |
| Chemical structure | ![Arctigenin [7770-78-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0119.png "Arctigenin [7770-78-7]") |
| Molecular Formula | C21H24O6 |
| CAS Number | 7770-78-7 |
| PubChem identifier | 64981 |
| SMILES | OC(C=C3)=C(OC)C=C3C[C@@H](C(OC2)=O)[C@H]2CC1=CC(OC)=C(OC)C=C1 |
| InChiKey | NQWVSMVXKMHKTF-JKSUJKDBSA-N |
Technical guides
Understanding purity and quality - a guide for life scientistsReferences for Arctigenin
References are publications that support the biological activity of the product
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Arctigenin anti-tumor activity in bladder cancer T24 cell line through induction of cell-cycle arrest and apoptosis.
Yang S et al (2012) Anat Rec (Hoboken) 295(8) : 1260-6. -
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.
Cho MK et al (2004) 4(10-11) : 1419-29 -
Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor.
Jang YP et al (2002) J Neurosci Res 68(2) : 233-40. -
Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.
Cho MK et al (2002) Int Immunopharmacol 2(1) : 105-16.