Potent MAP kinase kinase (MKK/MEK) inhibitor (IC50 = 1 nM for MKK1/MEK1). Antiviral, anti-cancer, antioxidant and anti-inflammatory compound. Inhibits iNOS expression by suppressing 1-κBα phosphorylation and nuclear translocation of p65 (IC50 = 10 nM). Shows neuroprotective actions.
Solubility & Handling
Solubility overview
Soluble in ethanol (25mM, gentle warming) or DMSO (100mM)
Storage instructions
-20°C (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-alpha inhibition.
Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages.
Cho MK et al (2002) Int Immunopharmacol 2(1) : 105-16.
![Arctigenin [7770-78-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0119.png "Arctigenin [7770-78-7]")
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