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Biological Data
| Biological description | Plasmodium falciparum SERCA orthologue (PfATP6) inhibitor (Ki = 150 nM). Thought to generate cytotoxic C-radicals. Shows anti-malarial, anti-proliferative and anti-neoplastic actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (75mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (3R,5aS,6R,8aS,9R,12S,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1, 2-benzodioxepin-10(3H)-one |
| Chemical structure | ![Artemisinin [63968-64-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Artemisinin [63968-64-9]") |
| Molecular Formula | C15H22O5 |
| SMILES | O=C1O[C@]([H])(O[C@@](OO4)(C)CC3)[C@]24[C@](CC[C@@H](C)[C@]32[H])([H])[C@H]1C |
| InChiKey | BLUAFEHZUWYNDE-NNWCWBAJSA-N |
References for Artemisinin
References are publications that support the biological activity of the product
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Artemisinin inhibits neuroblastoma proliferation through activation of AHP-activated protein kinase (AMPK) signaling.
Tan WQ et al (2014) Pharmazie 69(6) : 468-72. -
Considerations on the mechanism of action of artemisinin antimalarials: part 1--the 'carbon radical' and 'heme' hypotheses.
Haynes RK et al (2013) Infect Disord Drug Targets 13(4) : 217-77. -
Artemisinins target the SERCA of Plasmodium falciparum.
Eckstein-Ludwig U et al (2003) Nature 424(6951) : 957-61.
Plasmodium falciparum SERCA orthologue inhibitor
![Artemisinin [63968-64-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1115.png "Artemisinin [63968-64-9]")
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