G protein coupled receptors
G-protein-coupled receptors (also known as GPCRs, transmembrane receptors, or 7-TM receptors), are integral membrane proteins that contain seven membrane-spanning domains (helices). They are coupled to heterotrimeric G proteins on the intracellular side of the cell membrane. Ligand binding causes a conformational change in the GPCR, that is then transmitted to the G protein, activating a signal transduction pathway. Researchers can save up to 50% on GPCR receptor agonists, antagonists and allosteric modulators from Hello Bio - they are up to half the price of other suppliers.
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ω-Conotoxin MVIIC (HB1219)
Description:N-, P- and Q-type voltage-dependent Ca2+ channel blocker
Purity:>99%
IEM-1460 (HB0338)
Description:Competitive, selective, GluA2 (GluR2)-lacking AMPA receptor blocker
Purity:>98%
KC 12291 hydrochloride (HB1019)
Description:Atypical voltage-gated sodium channel blocker
Purity:>97%