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Gap19

(HB5162)
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Technical documents: CoA Datasheet

Product overview

Name Gap19
Purity >95%
Description Cx43 hemichannel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Cx43 hemichannel blocker. Shows no effect on gap junction coupling or at Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and reduces infact size in a mouse ischemia model. Inhibits astroglial Cx43 hemichannels in a dose-dependent manner, without affecting gap junction channels.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in water (1 mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >95%
Molecular Weight 1161.46
Molecular Formula C55H96N14O13
CAS Number 1507930-57-5
PubChem identifier 91691126
SMILES [H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O
Source Synthetic
InChiKey IEAKEKFIXUZWEH-PKMKMBMKSA-N

References for Gap19

References are publications that support the biological activity of the product

  • Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

    Lissoni A et al (2020) International journal of molecular sciences 21 :
    Read more (PubMedID: 33027889)

  • The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

    Abudara V et al (2014) Frontiers in cellular neuroscience 8 : 306
    Read more (PubMedID: 25374505)

  • Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

    Wang N et al (2013) Basic research in cardiology 108 : 309
    Read more (PubMedID: 23184389)

3 Item(s)

Related Products
Grouped product items
Order: HB5162
Pack PriceQty
1mg
$155
Cx43 hemichannel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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