Gap19

Name: Gap19
Brand: hello bio
SKU: HB5162
Price: 155 USD
Availability: InStock

(HB5162)

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Technical documents: CoA Datasheet

Product overview

Name

Gap19

Purity

>95%

Description

Cx43 hemichannel blocker

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3)

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Biological Data

Biological description

Cx43 hemichannel blocker. Shows no effect on gap junction coupling or at Panx-1 channels. Reduces mitochondrial potassium influx in cardiomyocytes and reduces infact size in a mouse ischemia model. Inhibits astroglial Cx43 hemichannels in a dose-dependent manner, without affecting gap junction channels.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in water (1 mg/ml)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>95%

Molecular Weight

1161.46

Molecular Formula

C₅₅H₉₆N₁₄O₁₃

CAS Number

1507930-57-5

PubChem identifier

91691126

SMILES

[H]N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CCCCN)C(O)=O

Source

Synthetic

InChiKey

IEAKEKFIXUZWEH-PKMKMBMKSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Gap19

References are publications that support the biological activity of the product

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.
Lissoni A et al (2020) International journal of molecular sciences 21 :
Read more (PubMedID: 33027889)
The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.
Abudara V et al (2014) Frontiers in cellular neuroscience 8 : 306
Read more (PubMedID: 25374505)
Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.
Wang N et al (2013) Basic research in cardiology 108 : 309
Read more (PubMedID: 23184389)

Cx43 hemichannel blocker

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Order: HB5162
Pack	Price	Qty
1mg	$155

Gap19

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Gap19

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

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New Products in this Area

Gap19

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Gap19

Gap19, a Cx43 Hemichannel Inhibitor, Acts as a Gating Modifier That Decreases Main State Opening While Increasing Substate Gating.

The connexin43 mimetic peptide Gap19 inhibits hemichannels without altering gap junctional communication in astrocytes.

Selective inhibition of Cx43 hemichannels by Gap19 and its impact on myocardial ischemia/reperfusion injury.

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Tell us about your publication!

Captcha

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