Product overview

Name Dofetilide
Alternative names Tikosyn, UK 68798
Purity >99%
Description Selective potassium channel blocker
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Biological Data

Biological description Selective potassium channel blocker. Inhibits Kv11.1 (hERG) channels (IC50 = 0.32 µM) and rapid delayed-rectifier K+ current (IKr). Increases the duration and refractory period of cardiac action potentials. Shows class III antiarrhythmic actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 1-(4-Methanesulphonamidophenoxy)-2-[N-(4-methanesulphonamidophenethyl)-N-methylamino] ethane
Molecular Weight 441.56
Chemical structure Dofetilide  [115256-11-6] Chemical Structure
Molecular Formula C19H27N3O5S2
CAS Number 115256-11-6
PubChem identifier 71329
InChi InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
MDL number MFCD00869707

References for Dofetilide

References are publications that support the biological activity of the product
  • Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study.

    Saiz J et al (2011) IEEE Trans Biomed Eng 58(1) : 43-53.
  • Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels.

    Ficker E et al (2001) Mol Pharmacol 60(6) : 1343-8.
  • Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide.

    Carmeliet E (1992) J Pharmacol Exp Ther 262(2) : 809-17.
  • UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells.

    Gwilt M et al (1991) J Pharmacol Exp Ther 256(1) : 318-24.

4 Item(s)

These publications cite the use of Dofetilide purchased from Hello Bio:
  • The K<sub>Ca</sub>2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts

    Kirchhoff JE et al (2019) Front Pharmacol 10 : 668
    PubMedID: 31275147

1 Item