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Images Dofetilide product vial image | Hello Bio
Dofetilide product vial image | Hello Bio Biological Data Biological description Selective potassium channel blocker. Inhibits Kv 11.1 (hERG) channels (IC50 = 0.32 µM) and rapid delayed-rectifier K+ current (IKr ). Increases the duration and refractory period of cardiac action potentials. Shows class III antiarrhythmic actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 1-(4-Methanesulphonamidophenoxy)-2-[N -(4-methanesulphonamidophenethyl)-N -methylamino] ethane
Chemical structure
Molecular Formula C19 H27 N3 O5 S2
SMILES CN(CCC1=CC=C(C=C1)NS(=O)(=O)C)CCOC2=CC=C(C=C2)NS(=O)(=O)C
InChi InChI=1S/C19H27N3O5S2/c1-22(13-12-16-4-6-17(7-5-16)20-28(2,23)24)14-15-27-19-10-8-18(9-11-19)21-29(3,25)26/h4-11,20-21H,12-15H2,1-3H3
InChiKey IXTMWRCNAAVVAI-UHFFFAOYSA-N
References for Dofetilide References are publications that support the biological activity of the product
Effects of the antiarrhythmic drug dofetilide on transmural dispersion of repolarization in ventriculum. A computer modeling study. Saiz J et al (2011) IEEE Trans Biomed Eng 58(1) : 43-53. Molecular determinants of inactivation and dofetilide block in ether a-go-go (EAG) channels and EAG-related K(+) channels. Ficker E et al (2001) Mol Pharmacol 60(6) : 1343-8. Voltage- and time-dependent block of the delayed K+ current in cardiac myocytes by dofetilide. Carmeliet E (1992) J Pharmacol Exp Ther 262(2) : 809-17. UK-68,798: a novel, potent and highly selective class III antiarrhythmic agent which blocks potassium channels in cardiac cells. Gwilt M et al (1991) J Pharmacol Exp Ther 256(1) : 318-24.
Publications
These publications cite the use of Dofetilide purchased from Hello Bio:
The K<sub>Ca</sub>2 Channel Inhibitor AP14145, But Not Dofetilide or Ondansetron, Provides Functional Atrial Selectivity in Guinea Pig Hearts Kirchhoff JE et al (2019) Front Pharmacol 10 : 668
Selective potassium channel blocker
![Dofetilide [115256-11-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1078.png "Dofetilide [115256-11-6]")
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