The store will not work correctly in the case when cookies are disabled.
Images
E-4031 dihydrochloride product vial image | Hello Bio
E-4031 dihydrochloride product vial image | Hello Bio
Biological Data
| Biological description | Potent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions. |
Solubility & Handling
| Storage instructions | Room temperature (desiccate) |
| Solubility overview | Soluble in water (100mM), and in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride |
| Chemical structure | ![E-4031 dihydrochloride [113559-13-0] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "E-4031 dihydrochloride [113559-13-0]") |
| Molecular Formula | C21H27N3O3S.2HCl |
| PubChem identifier | 3087190 |
| SMILES | CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl |
| InChi | InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H |
| InChiKey | ZQBNWMFBOSOOLX-UHFFFAOYSA-N |
References for E-4031 dihydrochloride
References are publications that support the biological activity of the product
-
Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.
Kim I et al (2005) J Appl Physiol (1985) 98(4) : 1469-77. -
Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.
Zhou Z et al (1998) Biophys J 74(1) : 230-41. -
Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.
Wettwer E et al (1991) J Cardiovasc Pharmacol 17(3) : 480-7.
Potent, selective Kv11.1 channel blocker
![E-4031 dihydrochloride [113559-13-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1080.png "E-4031 dihydrochloride [113559-13-0]")
Understanding purity and quality - a guide for life scientists
