My Cart
My account
Menu
Main Menu

E-4031 dihydrochloride

(HB1080)
Be the first to add a publication
Technical documents: SDS CoA Datasheet
1  Review
Top Reviews:
100% of 100
Add Your Review
Add to Wish List

Product overview

Name E-4031 dihydrochloride
Purity >98%
Description Potent, selective Kv11.1 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) References (3) Frequently bought together
Write Your Own Review
You're reviewing:E-4031 dihydrochloride
Rate this item:

Images

E-4031 dihydrochloride product vial image | Hello Bio
E-4031 dihydrochloride product vial image | Hello Bio

E-4031 dihydrochloride product vial image | Hello Bio

E-4031 dihydrochloride product vial image | Hello Bio

Biological Data

Biological description Potent and selective Kv11.1 (hERG) channel blocker (IC50 = 7.7 nM in HEK 293 cells). Delayed rectifier K2+ current inhibitor. Shows antiarrhythmic actions.

Solubility & Handling

Solubility overview Soluble in water (100mM), and in DMSO (50mM)
Storage instructions Room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name N-[4-[[1-[2-(6-Methyl-2-pyridinyl)ethyl]-4-piperidinyl]carbonyl]phenyl]methanesulfonamide dihydrochloride
Molecular Weight 474.44
Chemical structure E-4031 dihydrochloride [113559-13-0] Chemical Structure
Molecular Formula C21H27N3O3S.2HCl
CAS Number 113559-13-0
PubChem identifier 3087190
SMILES CC1=NC(=CC=C1)CCN2CCC(CC2)C(=O)C3=CC=C(C=C3)NS(=O)(=O)C.Cl.Cl
Source Synthetic
InChi InChI=1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChiKey ZQBNWMFBOSOOLX-UHFFFAOYSA-N
MDL number MFCD01754739
Appearance White solid

References for E-4031 dihydrochloride

References are publications that support the biological activity of the product

  • Postnatal development of E-4031-sensitive potassium current in rat carotid chemoreceptor cells.

    Kim I et al (2005) J Appl Physiol (1985) 98(4) : 1469-77.
    Read more (PubMedID: 15591286)

  • Properties of HERG channels stably expressed in HEK 293 cells studied at physiological temperature.

    Zhou Z et al (1998) Biophys J 74(1) : 230-41.
    Read more (PubMedID: 9449325)

  • Effects of the new class III antiarrhythmic drug E-4031 on myocardial contractility and electrophysiological parameters.

    Wettwer E et al (1991) J Cardiovasc Pharmacol 17(3) : 480-7.
    Read more (PubMedID: 1711611)

3 Item(s)

Related Products
Grouped product items
Order: HB1080
Pack PriceQty
10mg
$158
50mg
$639
Potent, selective Kv11.1 channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com

Related Products

ZD 7288
Code:
HB1152
Pack:
10mg, 50mg, 10mM (add 1ml water), 50mM (add 1ml water)
Price:
$140, $579, $78, $283
HCN channel blocker. Modulates sino-atrial node function.
Tetrodotoxin citrate
Code:
HB1035
Pack:
1mg
Price:
$267
Potent, selective, use-dependent Na+ channel blocker. Citrate Salt.
ω-Conotoxin GVIA
Code:
HB1218
Pack:
100μg, 250μg, 500μg, 1mg
Price:
$127, $308, $354, $573
Potent, selective Cav2.2 (N-type) channel blocker