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Biological Data Biological description Cav 2.1 (P/Q-type) and Cav 2.2 (N-type) voltage-dependent Ca2+ channel blocker. Peptide neurotoxin.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (1mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name H-Cys(1)-Lys-Gly-Lys-Gly-Ala-Pro-Cys(2)-Arg-Lys-Thr-Met-Tyr-Asp-Cys(3)-Cys(1)-Ser-Gly-Ser-Cys(2)-Gly-Arg-Arg-Gly-Lys-Cys(3)-NH2
Molecular Formula C106 H178 N40 O32 S7
PubChem identifier 56841670
SMILES C[C@H]1C(=O)N2CCC[C@H]2C(=O)N[C@H]3CSSC[C@H]4C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N1)CCCCN)CCCCN)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N4)CO)CO)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC3=O)CCCNC(=N)N)CCCCN)[C@@H](C)O)CCSC)CC5=CC=C(C=C5)O)CC(=O)O)C(=O)N)CCCCN)CCCNC(=N)N)CCCNC(=N)N
InChi InChI=1S/C106H178N40O32S7/c1-53-103(178)146-36-15-23-75(146)101(176)144-74-52-185-183-49-71-89(164)126-43-79(154)130-62(21-13-34-120-105(115)116)90(165)133-60(20-12-33-119-104(113)114)87(162)124-42-78(153)129-61(18-6-10-31-109)91(166)140-70(83(112)158)48-
InChiKey FHVUTHWUIUXZBY-QLANQDRJSA-N
References for ω-Conotoxin MVIIC References are publications that support the biological activity of the product
Omega-conotoxin MVIIC attenuates neuronal apoptosis in vitro and improves significant recovery after spinal cord injury in vivo in rats. Oliveira KM et al (2014) Int J Clin Exp Pathol 7(7) : 3524-36. Inhibition of calcium channels in rat central and peripheral neurons by omega-conotoxin MVIIC. McDonough et al (1996) J Neurosci 16(8) : 2612-23 Identification of three subunits of the high affinity omega-conotoxin MVIIC-sensitive Ca2+ channel. Liu H et al (1996) J Biol Chem 271(23) : 13804-10.
N-, P- and Q-type voltage-dependent Ca2+ channel blocker
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