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Biological Data

Biological description Selective L-type voltage-operated calcium channel (VOCC) blocker (pIC50 = 8.30 mM). Exhibits selectivity for L-type channels over L-, N-, P/Q-, and R-type channels. Displays vascular relaxant, vascular protective, antihypertensive and antianginal properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Molecular Weight 384.25
Chemical structure Felodipine  [72509-76-3] Chemical Structure
Molecular Formula C18H19Cl2NO4
CAS Number 72509-76-3
PubChem identifier 3333
SMILES ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1
InChiKey RZTAMFZIAATZDJ-UHFFFAOYSA-N

References for Felodipine

References are publications that support the biological activity of the product
  • Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues.

    Angus JA et al (2000) Clin Exp Pharmacol Physiol 27(12) : 1019-21.
  • Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.

    Furukawa T et al (1999) J Pharmacol Exp Ther 291(2) : 464-73.
  • Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells.

    Hishikawa K et al (1998) Hypertension 32(6) : 1011-5.
  • Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists.

    Sarsero D et al (1998) Br J Pharmacol 125(1) : 109-19.