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Biological Data
| Biological description | Selective L-type voltage-operated calcium channel (VOCC) blocker (pIC50 = 8.30 mM). Exhibits selectivity for L-type channels over L-, N-, P/Q-, and R-type channels. Displays vascular relaxant, vascular protective, antihypertensive and antianginal properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester |
| Chemical structure | ![Felodipine [72509-76-3] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Felodipine [72509-76-3]") |
| Molecular Formula | C18H19Cl2NO4 |
| SMILES | ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1 |
| InChiKey | RZTAMFZIAATZDJ-UHFFFAOYSA-N |
References for Felodipine
References are publications that support the biological activity of the product
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Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues.
Angus JA et al (2000) Clin Exp Pharmacol Physiol 27(12) : 1019-21. -
Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.
Furukawa T et al (1999) J Pharmacol Exp Ther 291(2) : 464-73. -
Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells.
Hishikawa K et al (1998) Hypertension 32(6) : 1011-5. -
Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists.
Sarsero D et al (1998) Br J Pharmacol 125(1) : 109-19.
Selective L-type VOCC blocker
![Felodipine [72509-76-3] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1222.png "Felodipine [72509-76-3]")
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