My Cart
My account
Menu
Main Menu

Felodipine

(HB1222)
Be the first to add a publication
Technical documents: Datasheet
Be the first to review this product
Add to Wish List

Product overview

Name Felodipine
Purity >98%
Description Selective L-type VOCC blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
Write Your Own Review
You're reviewing:Felodipine
Rate this item:

Biological Data

Biological description Selective L-type voltage-operated calcium channel (VOCC) blocker (pIC50 = 8.30 mM). Exhibits selectivity for L-type channels over L-, N-, P/Q-, and R-type channels. Displays vascular relaxant, vascular protective, antihypertensive and antianginal properties.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (100mM)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Molecular Weight 384.25
Chemical structure Felodipine [72509-76-3] Chemical Structure
Molecular Formula C18H19Cl2NO4
CAS Number 72509-76-3
PubChem identifier 3333
SMILES ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1
InChiKey RZTAMFZIAATZDJ-UHFFFAOYSA-N

References for Felodipine

References are publications that support the biological activity of the product

  • Quantitative analysis of vascular to cardiac selectivity of L- and T-type voltage-operated calcium channel antagonists in human tissues.

    Angus JA et al (2000) Clin Exp Pharmacol Physiol 27(12) : 1019-21.
    Read more (PubMedID: 11117223)

  • Selectivities of dihydropyridine derivatives in blocking Ca(2+) channel subtypes expressed in Xenopus oocytes.

    Furukawa T et al (1999) J Pharmacol Exp Ther 291(2) : 464-73.
    Read more (PubMedID: 10525060)

  • Felodipine inhibits free-radical production by cytokines and glucose in human smooth muscle cells.

    Hishikawa K et al (1998) Hypertension 32(6) : 1011-5.
    Read more (PubMedID: 9856965)

  • Human vascular to cardiac tissue selectivity of L- and T-type calcium channel antagonists.

    Sarsero D et al (1998) Br J Pharmacol 125(1) : 109-19.
    Read more (PubMedID: 9776350)

4 Item(s)

Grouped product items
Order: HB1222
Pack PriceQty
10mg
$106
50mg
$221
100mg
$388
Selective L-type VOCC blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

Contact Us

Call 609-683-7500
Fax 609-228-4994

customercare-usa@hellobio.com