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Isradipine

(HB1223)
Publications (4)

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Product overview

Name Isradipine
Alternative names PN 200-110
Purity >99%
Description L-type voltage gated calcium channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (1) Publications (4) References (4) Frequently bought together
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Isradipine product vial image | Hello Bio
Isradipine product vial image | Hello Bio

Isradipine product vial image | Hello Bio

Isradipine product vial image | Hello Bio

Biological Data

Biological description L-type voltage gated calcium channel blocker (EC50 = 1.4 nM). Highest affinity for Cav1.3 and Cav1.2 channels over Cav1.4. Displays neuroprotective properties. Blood brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (50mM) or ethanol (20mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Molecular Weight 371.39
Chemical structure Isradipine [75695-93-1] Chemical Structure
Molecular Formula C19H21N3O5
CAS Number 75695-93-1
PubChem identifier 3784
SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
InChi InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChiKey HMJIYCCIJYRONP-UHFFFAOYSA-N
MDL number MFCD00153820
Appearance Yellow solid

References for Isradipine

References are publications that support the biological activity of the product

  • L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.

    Anekonda TS et al (2011) Neurobiol Dis 41(1) : 62-70.
    Read more (PubMedID: 20816785)

  • The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.

    Ilijic E et al (2011) Neurobiol Dis 43(2) : 364-71.
    Read more (PubMedID: 21515375)

  • Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.

    Sinnegger-Brauns MJ et al (2009) Mol Pharmacol 75(2) : 407-14.
    Read more (PubMedID: 19029287)

  • PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.

    Hof RP et al (1984) J Cardiovasc Pharmacol 6(3) : 399-406.
    Read more (PubMedID: 6202964)

4 Item(s)

Publications
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These publications cite the use of Isradipine purchased from Hello Bio:

  • Nav1. 2 and BK channels interaction shapes the action potential in the axon initial segment

    Canepari et al (2022) Biorxiv : https://doi.org/10.1101/2022.04.12.488116

  • Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons

    Lahiri and Bevan (2020) Neuron 106(2) : 277-290
    PubMedID: 32075716

  • Characterization of calcium signals generated by activation of the two excitatory synaptic inputs in Purkinje neurons

    Ouares et al (2019) University of Paris : Thesis

  • Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.

    Kurowski et al (2018) Front Cell Neurosci. : 12:93
    PubMedID: 29740284

4 Item(s)

Related Products
Grouped product items
Order: HB1223
Pack PriceQty
10mg
$86
50mg
$370
L-type voltage gated calcium channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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