The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Images Isradipine product vial image | Hello Bio
Isradipine product vial image | Hello Bio Biological Data Biological description L-type voltage gated calcium channel blocker (EC50 = 1.4 nM). Highest affinity for Cav 1.3 and Cav 1.2 channels over Cav 1.4. Displays neuroprotective properties. Blood brain barrier permeable.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (50mM) or ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Chemical structure
Molecular Formula C19 H21 N3 O5
SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
InChi InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChiKey HMJIYCCIJYRONP-UHFFFAOYSA-N
References for Isradipine References are publications that support the biological activity of the product
L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease. Anekonda TS et al (2011) Neurobiol Dis 41(1) : 62-70. The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease. Ilijic E et al (2011) Neurobiol Dis 43(2) : 364-71. Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms. Sinnegger-Brauns MJ et al (2009) Mol Pharmacol 75(2) : 407-14. PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta. Hof RP et al (1984) J Cardiovasc Pharmacol 6(3) : 399-406.
Publications
These publications cite the use of Isradipine purchased from Hello Bio:
Nav1. 2 and BK channels interaction shapes the action potential in the axon initial segment Canepari et al (2022) Biorxiv : https://doi.org/10.1101/2022.04.12.488116
Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons Lahiri and Bevan (2020) Neuron 106(2) : 277-290 Characterization of calcium signals generated by activation of the two excitatory synaptic inputs in Purkinje neurons Ouares et al (2019) University of Paris : Thesis
Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons. Kurowski et al (2018) Front Cell Neurosci. : 12:93
L-type voltage gated calcium channel blocker
![Isradipine [75695-93-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1223.png "Isradipine [75695-93-1]")
Understanding purity and quality - a guide for life scientists
