Isradipine

(HB1223)
Technical documents: SDS CoA Datasheet

Product overview

Name Isradipine
Description L-type voltage gated calcium channel blocker
Alternative names PN 200-110
Purity >99%
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Images

Isradipine product vial image | Hello Bio

Biological Data

Biological description L-type voltage gated calcium channel blocker (EC50 = 1.4 nM). Highest affinity for Cav1.3 and Cav1.2 channels over Cav1.4. Displays neuroprotective properties. Blood brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (50mM) or ethanol (20mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 4-(2,1,3-Benzoxadiazol-4-yl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinecarboxylic acid methyl 1-methylethyl ester
Molecular Weight 371.39
Chemical structure Isradipine  [75695-93-1] Chemical Structure
Molecular Formula C19H21N3O5
CAS Number 75695-93-1
PubChem identifier 3784
SMILES CC1=C(C(C(=C(N1)C)C(=O)OC(C)C)C2=CC=CC3=NON=C32)C(=O)OC
InChi InChI=1S/C19H21N3O5/c1-9(2)26-19(24)15-11(4)20-10(3)14(18(23)25-5)16(15)12-7-6-8-13-17(12)22-27-21-13/h6-9,16,20H,1-5H3
InChiKey HMJIYCCIJYRONP-UHFFFAOYSA-N
MDL number MFCD00153820
Appearance Yellow solid

References for Isradipine

References are publications that support the biological activity of the product
  • L-type voltage-gated calcium channel blockade with isradipine as a therapeutic strategy for Alzheimer's disease.

    Anekonda TS et al (2011) Neurobiol Dis 41(1) : 62-70.
  • The L-type channel antagonist isradipine is neuroprotective in a mouse model of Parkinson's disease.

    Ilijic E et al (2011) Neurobiol Dis 43(2) : 364-71.
  • Expression and 1,4-dihydropyridine-binding properties of brain L-type calcium channel isoforms.

    Sinnegger-Brauns MJ et al (2009) Mol Pharmacol 75(2) : 407-14.
  • PN 200-110, a new calcium antagonist: electrophysiological, inotropic, and chronotropic effects on guinea pig myocardial tissue and effects on contraction and calcium uptake of rabbit aorta.

    Hof RP et al (1984) J Cardiovasc Pharmacol 6(3) : 399-406.
Publications
These publications cite the use of Isradipine purchased from Hello Bio:
  • Dopaminergic Transmission Rapidly and Persistently Enhances Excitability of D1 Receptor-Expressing Striatal Projection Neurons

    Lahiri and Bevan (2020) Neuron 106(2) : 277-290
    PubMedID: 32075716
  • Ionic Mechanism Underlying Rebound Depolarization in Medial Prefrontal Cortex Pyramidal Neurons.

    Kurowski et al (2018) Front Cell Neurosci. : 12:93
    PubMedID: 29740284

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