Receptors & Transporters

Potent, selective, use-dependent Na⁺ channel blocker. Citrate Salt.

TRPV2 channel inhibitor. Potent mast cell stabilizer.

Potent 5-HT₃ receptor antagonist. Also α7 nAChR partial agonist. Activates α7Q79G-GlyR chimeric ion channels.

Novel, potent, subtype-selective TRPV3 inhibitor

Highly potent, selective GluN2C/2D NMDAR antagonist

Potent, selective GluK1 subunit selective kainate receptor antagonist

Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist

NMDAR pan-PAM that potentiates all GluN2 subunits. Enhances LTD and decreases LTP. 

Ultrapotent PSEM agonist for PSAM⁴-GlyR and PSAM⁴-5HT3. Brain penetrant.

L-type Ca²⁺ channel blocker