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Verapamil hydrochloride

(HB1237)
Publications (1)

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Product overview

Name Verapamil hydrochloride
Purity >99%
Description L-type Ca2+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews Publications (1) References (4) Frequently bought together
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Biological Data

Biological description

L-type Ca2+ channel blocker and adrenergic antagonist.

Shows various biological actions - increases FRZB expression and decreases Wnt/β-catenin signalling in osteoarthritis and shows cardioprotective, vasodilator, anti-arrhythmic, anti-oxidative stress actions.

Recently investigated as part of COVID-19 compound repurposing.

Solubility & Handling

Solubility overview Soluble in water (50mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name α-[3-[[2-(3,4-Dimethoxyphenyl)ethyl]methylamino]propyl]-3,4-dimethoxy-α-(1-methylethyl) benzeneacetonitrile hydrochloride
Molecular Weight 491.07
Chemical structure Verapamil hydrochloride [152-11-4] Chemical Structure
Molecular Formula C27H38N2O4.HCl
CAS Number 152-11-4
PubChem identifier 62969
SMILES CC(C)C(CCCN(C)CCC1=CC(=C(C=C1)OC)OC)(C#N)C2=CC(=C(C=C2)OC)OC.Cl
InChi InChI=1S/C27H38N2O4.ClH/c1-20(2)27(19-28,22-10-12-24(31-5)26(18-22)33-7)14-8-15-29(3)16-13-21-9-11-23(30-4)25(17-21)32-6;/h9-12,17-18,20H,8,13-16H2,1-7H3;1H
InChiKey DOQPXTMNIUCOSY-UHFFFAOYSA-N
MDL number MFCD00055208

References for Verapamil hydrochloride

References are publications that support the biological activity of the product

  • A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

    Krogan et al (2020) Nature 7816 : 459-468
    Read more (PubMedID: 32353859)

  • Comparative study of the effect of verapamil and vitamin D on iron overload-induced oxidative stress and cardiac structural changes in adult male rats.

    Abd Allah ES et al (2014) Pathophysiology :
    Read more (PubMedID: 25092628)

  • Verapamil protects against cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling.

    Takamatsu A et al (2014) PLoS One 9(3) : e92699.
    Read more (PubMedID: 24658359)

  • Robust anti-arrhythmic efficacy of verapamil and flunarizine against dofetilide-induced TdP arrhythmias is based upon a shared and a different mode of action.

    Oros A et al (2010) Br J Pharmacol 161(1) : 162-75.
    Read more (PubMedID: 20718748)

4 Item(s)

Publications
Submit Yours Now
These publications cite the use of Verapamil hydrochloride purchased from Hello Bio:

  • Npas4 regulates medium spiny neuron physiology and gates cocaine-induced hyperlocomotion

    Lissek T et al (2021) EMBO Rep 22(12) : e51882
    PubMedID: 34661342

1 Item

Related Products
Grouped product items
Order: HB1237
Pack PriceQty
1g
$75
50mM (add 1ml water)
$42
L-type Ca2+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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