Trpvicin

Novel, potent, subtype-selective TRPV3 inhibitor which antagonizes both the hTRPV3-WT and the pathogenic mutant hTRPV3-G573S channels (IC₅₀ values are 0.41µM and 0.22µM respectively and 0.38µM at mTRPV3). Inhibits the TRPV3 channel by stabilizing it in a closed state. Attenuates TRPV3-mediated responses to show pharmacological potential in the inhibition of itch and hair loss in mouse models.