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UBP 310

(HB0628)
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Technical documents: SDS CoA Datasheet
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Product overview

Name UBP 310
Purity >98%
Description Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews References (3) Frequently bought together
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UBP 310 product vial image | Hello Bio
UBP 310 product vial image | Hello Bio

UBP 310 product vial image | Hello Bio

UBP 310 product vial image | Hello Bio

Biological Data

Biological description Potent and selective GluK1 (formerly GluR5) and GluK3 (formerly GluR7) subunit selective kainate receptor antagonist (Kb = 10 nM and IC50 = 23 nM respectively). IC50 values are > 100 µM for GluA2, GluK6, GluK2/3 and GluK6/GluK2 respectively. Active at AMPA receptors and inactive against NMDA and Group I mGlu receptors at concentrations of up to 10 µM.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (S)-1-(2-Amino-2-carboxyethyl)-3-(2 -carboxy-thiophene-3-yl-methyl)-5-methylpyrimidine-2,4-dione
Molecular Weight 353.35
Chemical structure UBP 310 [902464-46-4] Chemical Structure
Molecular Formula C14H15N3O6S
CAS Number 902464-46-4
PubChem identifier 6420160
SMILES CC1=CN(C(=O)N(C1=O)CC2=C(SC=C2)C(=O)O)C[C@@H](C(=O)O)N
InChi InChI=1S/C14H15N3O6S/c1-7-4-16(6-9(15)12(19)20)14(23)17(11(7)18)5-8-2-3-24-10(8)13(21)22/h2-4,9H,5-6,15H2,1H3,(H,19,20)(H,21,22)/t9-/m0/s1
InChiKey ZTAZUCRXCRXNSU-VIFPVBQESA-N
Appearance White solid

References for UBP 310

References are publications that support the biological activity of the product

  • Antagonism of recombinant and native GluK3-containing kainate receptors.

    Perrais D et al (2009) Neuropharmacology 56(1) : 131-40.
    Read more (PubMedID: 18761361)

  • Synthesis and pharmacological characterization of N3-substituted willardiine derivatives: role of the substituent at the 5-position of the uracil ring in the development of highly potent and selective GLUK5 kainate receptor antagonists.

    Dolman NP et al (2007) J Med Chem 50(7) : 1558-70.
    Read more (PubMedID: 17348638)

  • Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists.

    Mayer ML et al (2006) J Neurosci 26(11) : 2852-61.
    Read more (PubMedID: 16540562)

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Order: HB0628
Pack PriceQty
10mg
$220
Potent, selective GluK1 / GluK3 subunit selective kainate receptor antagonist
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