Stem cells
Small molecule pharmacological tools can be used to manipulate signalling pathways during the in vitro culture of stem cells. These small molecules can be used to target signaling pathways that control cell proliferation and differentiation. Researchers can save up to 50% on high purity stem cell research tools such as ROCK inhibitor Y 27632, A83-01 and CHIR 99021 from Hello Bio - they are around half the price of other suppliers.
View products:  Differentiation | Organoids | Proliferation/Self-renewal | Reprogramming | Stem Cell Signaling View resources: Stem Cell Research Tools & Mini-Reviews
A83-01 (HB3218)
Description:Selective TGF-βRI (ALK5), ALK4 and ALK7 inhibitor. Maintains human hiPSC self renewal, 3D growth matrix component and promotes long-term organoid growth. Aids fibroblast to NSC/cardiomyocyte reprogramming.
Purity:>98%
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CHIR 99021 (HB1261)
Description:Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.
Purity:>98%
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DBZ (Dibenzazepine) (HB3419)
Description:γ-secretase and Notch pathway inhibitor. Stimulates iPSC formation.
Purity:>99%
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PD 0325901 (HB2240)
Description:Potent MEK1 and MEK2 inhibitor. Enhances iPSCs generation. Used in organoid production.
Purity:>98%
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SB 431542 (HB3555)
Description:Potent, selective TGF-βRI ALK5, ALK4, ALK7 inhibitor. Induces sheet formation, proliferation, differentiation of ESC-derived endothelial cells and replaces SOX2 in reprogramming protocols.3D growth matrix component and can be used in production of organoids.
Purity:>98%
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Valproic acid sodium salt (HB0867)
Description:Histone deacetylase inhibitor. Shows multitude of biological actions. Enables pluripotent stem cell induction from somatic cells.
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Venlafaxine hydrochloride (HB1743)
Description:Serotonin/norepinephrine re-uptake inhibitor. Affects differentiation of NSCs.
Purity:>98%
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XAV 939 (HB0660)
Description:Potent tankyrase inhibitor. Wnt/β-catenin signaling inhibitor.
Purity:>98%
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ROCK inhibitor Y-27632 (HB2297)
Description:Y-27632 is a selective ROCK inhibitor. Frequently used 3D growth matrix component and for production of organoids. Also used when inducing neurons from fibroblasts. Manufactured to a high degree of optical purity.
Purity:>99%
