Group I (mGlu5, mGlu1)
Group I metabotropic glutamate receptors (mGlu1, mGlu5) are coupled with phospholipase C (PLC) via Gq proteins; activation causes increased levels of IP3 and diacylglycerol, with intracellullar Ca2+ release and protein kinase C (PKC) activation. Group I receptors are predominantly located post synaptically. Researchers can save 50% on group I metabotropic glutamate receptor agonists, antagonists, positive allosteric modulators (PAMs) and negative allosteric modulators (NAMs) from Hello Bio - they are up to half the price of other suppliers.
4-Aminopyridine (4-AP) (HB1073)
Description:Non-selective voltage gated K+ channel blocker
Purity:>99%
ω-Conotoxin MVIIC (HB1219)
Description:N-, P- and Q-type voltage-dependent Ca2+ channel blocker
Purity:>99%
Mibefradil dihydrochloride (HB1226)
Description:Potent, reversible T- / L-type Ca2+ channel blocker
Purity:>95%
ω-Agatoxin IVA (HB1212)
Description:Potent, selective P-type / Q-type Ca2+ channel blocker
Purity:>95%
SNX 482 (HB1235)
Description:Reported to be a potent, selective Cav2.3 (R-type) channel blocker
Purity:>95%