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Images SNX 482 product vial image | Hello Bio
SNX 482 product vial image | Hello Bio Biological Data Biological description Reported to be a potent and selective Cav 2.3 (R-type, α1E) channel blocker (IC50 = 30 nM) and shows incomplete inhibition of Cav 1.2 (L-type, α1C). Also shown to inhibit potassium Kv4.3 and Kv4.2 channels and to inhibit A-Type potassium current. Caution should therefore be used when interpreting effects of SNX-482 on cells and circuits when Kv4.3 and Kv4.2 channels are also present.
Shows antinociceptive actions.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name H-Gly-DL-Val-DL-Asp-DL-Lys-DL-Ala-Gly-DL-Cys(1)-DL-Arg-DL-Tyr-DL-Met-DL-Phe-Gly-Gly-DL-Cys(2)-DL-Ser-DL-Val-DL-Asn-DL-Asp-DL-Asp-DL-Cys(3)-DL-Cys(1)-DL-Pro-DL-Arg-DL-Leu-Gly-DL-Cys(2)-DL-His-DL-Ser-DL-Leu-DL-Phe-DL-Ser-DL-Tyr-DL-Cys(3)-DL-Ala-DL-Trp-DL-Asp-DL-Leu-DL-xiThr-DL-Phe-DL-Ser-DL-Asp-OH
Molecular Formula C192 H274 N52 O60 S7
PubChem identifier 90488787
SMILES CC(C)CC1C(=O)NCC(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC4=CNC=N4)CO)CC(C)C)CC5=CC=CC=C5)CO)CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC9=CC=CC=C9)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)O)C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)N3)CC2=CC=CC=C2)CCSC)CC2=CC=C(C=C2)O)CCCNC(=N)N)NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)CN)C(=O)N2CCCC2C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CC(=O)O)CC(=O)N)C(C)C)CO
InChi InChI=1S/C192H274N52O60S7/c1-91(2)57-114-157(270)207-79-146(257)213-135-85-306-307-86-136-183(296)237-133(83-248)179(292)242-153(95(9)10)187(300)231-124(67-141(195)252)170(283)228-126(69-148(260)261)173(286)229-127(70-149(262)263)174(287)239-138(184(297)2
InChiKey NSUPRLHDCFNOKD-UHFFFAOYSA-N
References for SNX 482 References are publications that support the biological activity of the product
Inhibition of A-type potassium current by the peptide toxin SNX-482 Kimm et al (2014) J Neurosci. 34(28) : 9182-9. Antagonism of R-type calcium channels significantly improves cerebral blood flow after subarachnoid hemorrhage in rats. Wang F et al (2010) J Neurotrauma 27(9) : 1723-32. The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain. Matthews EA et al (2007) Eur J Neurosci 25(12) : 3561-9. Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels. Bourinet E et al (2001) Biophys J 81(1) : 79-88.
Publications
These publications cite the use of SNX 482 purchased from Hello Bio:
GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals Bhandari et al. (2020) bioRxiv preprint : 1-50
Reported to be a potent, selective Cav 2.3 (R-type) channel blocker
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