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SNX 482

(HB1235)
Publications (1)
Technical documents: SDS CoA Datasheet
2  Reviews
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Product overview

Name SNX 482
Purity >95%
Description Reported to be a potent, selective Cav2.3 (R-type) channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (2) Publications (1) References (4) Frequently bought together
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Images

SNX 482 product vial image | Hello Bio
SNX 482 product vial image | Hello Bio

SNX 482 product vial image | Hello Bio

SNX 482 product vial image | Hello Bio

Biological Data

Biological description

Reported to be a potent and selective Cav2.3 (R-type, α1E) channel blocker (IC50 = 30 nM) and shows incomplete inhibition of Cav1.2 (L-type, α1C). Also shown to inhibit potassium Kv4.3 and Kv4.2 channels and to inhibit A-Type potassium current. Caution should therefore be used when interpreting effects of SNX-482 on cells and circuits when Kv4.3 and Kv4.2 channels are also present.

Shows antinociceptive actions.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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More Info

Chemical Data

Purity >95%
Chemical name H-Gly-DL-Val-DL-Asp-DL-Lys-DL-Ala-Gly-DL-Cys(1)-DL-Arg-DL-Tyr-DL-Met-DL-Phe-Gly-Gly-DL-Cys(2)-DL-Ser-DL-Val-DL-Asn-DL-Asp-DL-Asp-DL-Cys(3)-DL-Cys(1)-DL-Pro-DL-Arg-DL-Leu-Gly-DL-Cys(2)-DL-His-DL-Ser-DL-Leu-DL-Phe-DL-Ser-DL-Tyr-DL-Cys(3)-DL-Ala-DL-Trp-DL-Asp-DL-Leu-DL-xiThr-DL-Phe-DL-Ser-DL-Asp-OH
Molecular Weight 4495.01
Molecular Formula C192H274N52O60S7
CAS Number 203460-30-4
PubChem identifier 90488787
SMILES CC(C)CC1C(=O)NCC(=O)NC2CSSCC3C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(CSSCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CC4=CNC=N4)CO)CC(C)C)CC5=CC=CC=C5)CO)CC6=CC=C(C=C6)O)C(=O)NC(C)C(=O)NC(CC7=CNC8=CC=CC=C87)C(=O)NC(CC(=O)O)C(=O)NC(CC(C)C)C(=O)NC(C(C)O)C(=O)NC(CC9=CC=CC=C9)C(=O)NC(CO)C(=O)NC(CC(=O)O)C(=O)O)C(=O)NC(CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)N3)CC2=CC=CC=C2)CCSC)CC2=CC=C(C=C2)O)CCCNC(=N)N)NC(=O)CNC(=O)C(C)NC(=O)C(CCCCN)NC(=O)C(CC(=O)O)NC(=O)C(C(C)C)NC(=O)CN)C(=O)N2CCCC2C(=O)NC(C(=O)N1)CCCNC(=N)N)CC(=O)O)CC(=O)O)CC(=O)N)C(C)C)CO
InChi InChI=1S/C192H274N52O60S7/c1-91(2)57-114-157(270)207-79-146(257)213-135-85-306-307-86-136-183(296)237-133(83-248)179(292)242-153(95(9)10)187(300)231-124(67-141(195)252)170(283)228-126(69-148(260)261)173(286)229-127(70-149(262)263)174(287)239-138(184(297)2
InChiKey NSUPRLHDCFNOKD-UHFFFAOYSA-N

References for SNX 482

References are publications that support the biological activity of the product

  • Inhibition of A-type potassium current by the peptide toxin SNX-482

    Kimm et al (2014) J Neurosci. 34(28) : 9182-9.
    Read more (PubMedID: 25009251)

  • Antagonism of R-type calcium channels significantly improves cerebral blood flow after subarachnoid hemorrhage in rats.

    Wang F et al (2010) J Neurotrauma 27(9) : 1723-32.
    Read more (PubMedID: 20568961)

  • The Cav2.3 calcium channel antagonist SNX-482 reduces dorsal horn neuronal responses in a rat model of chronic neuropathic pain.

    Matthews EA et al (2007) Eur J Neurosci 25(12) : 3561-9.
    Read more (PubMedID: 17610575)

  • Interaction of SNX482 with domains III and IV inhibits activation gating of alpha(1E) (Ca(V)2.3) calcium channels.

    Bourinet E et al (2001) Biophys J 81(1) : 79-88.
    Read more (PubMedID: 11423396)

4 Item(s)

Publications
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These publications cite the use of SNX 482 purchased from Hello Bio:

  • GABAB receptor auxiliary subunits modulate Cav2.3-mediated release from medial habenula terminals

    Bhandari et al. (2020) bioRxiv preprint : 1-50

1 Item

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Grouped product items
Order: HB1235
Pack PriceQty
10μg
$161
100μg
$561
Reported to be a potent, selective Cav2.3 (R-type) channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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