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Images
Rufinamide product vial image | Hello Bio
Rufinamide product vial image | Hello Bio
Biological Data
| Biological description | Na+ channel blocker. Shows higher selectivity for Nav1.7. Also mGluR5 antagonist. A novel triazole derivative. Prolongs sodium channel inactivation. Displays anticonvulsant and antiepileptic actions. |
Solubility & Handling
| Storage instructions | room temperature (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-[(2,6-Difluorophenyl)methyl]-1H-1,2,3-triazole-4-carboxamide |
| Chemical structure | ![Rufinamide [106308-44-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Rufinamide [106308-44-5]") |
| Molecular Formula | C10H8F2N4O |
| PubChem identifier | 129228 |
| SMILES | O=C(N)C1=CN(CC2=C(F)C=CC=C2F)N=N1 |
| InChiKey | POGQSBRIGCQNEG-UHFFFAOYSA-N |
References for Rufinamide
References are publications that support the biological activity of the product
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Rufinamide attenuates mechanical allodynia in a model of neuropathic pain in the mouse and stabilizes voltage-gated sodium channel inactivated state.
Suter MR et al (2013) Anesthesiology 118(1) : 160-72. -
Rufinamide.
Arroyo S (2007) Neurotherapeutics 4(1) : 155-62. -
Rufinamide.
Deeks ED et al (2006) CNS Drugs 20(9) : 751-60
Publications
These publications cite the use of Rufinamide purchased from Hello Bio:
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Modulating voltage-gated sodium channels to enhance differentiation and sensitize glioblastoma cells to chemotherapy.
Giammello F et al (2024) Cell communication and signaling : CCS 22 : 434
![Rufinamide [106308-44-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1039.png "Rufinamide [106308-44-5]")
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