4-Aminopyridine (4-AP)

Technical documents: SDS CoA Datasheet
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Product overview

Name 4-Aminopyridine (4-AP)
Alternative names 4-AP, 4AP
Purity >99%
Description Non-selective voltage gated K+ channel blocker
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Biological Data

Biological description

4-Aminopyridine (4-AP) is a non-selective voltage gated K+ channel blocker which blocks Kv1.1 and Kv1.2 channels (IC50 values are 170 and 230 µM respectively).

4-aminopyridine facilitates synaptic and neuromuscular transmission.

4-AP shows proconvulsive actions.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100mM) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name 4-Aminopyridine
Molecular Weight 94.12
Chemical structure 4-Aminopyridine  [504-24-5] Chemical Structure
Molecular Formula C5H6N2
CAS Number 504-24-5
PubChem identifier 1727
InChi InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)
MDL number MFCD00006439
Appearance White solid

References for 4-Aminopyridine (4-AP)

References are publications that support the biological activity of the product
  • 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

    Göbel K et al (2013) Exp Neurol 248 : 62-71.
  • Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

    Lévesque M et al (2013) Epilepsia 54(4) : 596-604.
  • Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

    Wacker SJ et al (2012) ChemMedChem 7(10) : 1775-83.
  • Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.

    Tseng GN (1999) J Pharmacol Exp Ther 290(2) : 569-77.

4 Item(s)

These publications cite the use of 4-Aminopyridine (4-AP) purchased from Hello Bio:
  • Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs

    Naskar S et al (2021) Cell Rep 34(8) : 108774
    PubMedID: 33626343
  • Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus

    Banks PJ et al (2021) Cereb Cortex Commun 2(2) : tgab029
    PubMedID: 34296174
  • Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington's disease

    Surmeier et al et al (2021) Research Square https://doi.org/10.21203/rs.3.rs-1008365/v1
  • Biased Connectivity of Brain-wide Inputs to Ventral Subiculum Output Neurons

    Wee and MacAskill. (2020) Cell Rep. 30(11) : 3644-3654
    PubMedID: 32187537

4 Item(s)