4-Aminopyridine (4-AP)

Name: 4-Aminopyridine (4-AP)
Brand: Hello Bio
SKU: HB1073
Price: 69 USD
Availability: InStock
Rating: 100 (3 reviews)

(HB1073)

Publications (5)

Technical documents: SDS Datasheet

3 Reviews

Top Reviews:

100% of 100

Product overview

Name

4-Aminopyridine (4-AP)

Alternative names

4-AP, 4AP

Purity

>99%

Description

Non-selective voltage gated K⁺ channel blocker

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews (3) Publications (5) References (4) Frequently bought together

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Biological Data

Biological description

4-Aminopyridine (4-AP) is a non-selective voltage gated K⁺ channel blocker which blocks K_v1.1 and K_v1.2 channels (IC₅₀ values are 170 and 230 µM respectively).

4-aminopyridine facilitates synaptic and neuromuscular transmission.

4-AP shows proconvulsive actions.

Solubility & Handling

Solubility overview

Soluble in water (100mM) and in DMSO (100 mM)

Storage instructions

Room temperature

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

4-Aminopyridine

Molecular Weight

94.12

Chemical structure

Molecular Formula

C₅H₆N₂

CAS Number

504-24-5

PubChem identifier

1727

SMILES

C1=CN=CC=C1N

InChi

InChI=1S/C5H6N2/c6-5-1-3-7-4-2-5/h1-4H,(H2,6,7)

InChiKey

NUKYPUAOHBNCPY-UHFFFAOYSA-N

MDL number

MFCD00006439

Appearance

White solid

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for 4-Aminopyridine (4-AP)

References are publications that support the biological activity of the product

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.
Göbel K et al (2013) Exp Neurol 248 : 62-71.
Read more (PubMedID: 23748135)
Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.
Lévesque M et al (2013) Epilepsia 54(4) : 596-604.
Read more (PubMedID: 23521339)
Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.
Wacker SJ et al (2012) ChemMedChem 7(10) : 1775-83.
Read more (PubMedID: 22473914)
Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.
Tseng GN (1999) J Pharmacol Exp Ther 290(2) : 569-77.
Read more (PubMedID: 10411564)

Publications

Submit Yours Now

These publications cite the use of 4-Aminopyridine (4-AP) purchased from Hello Bio:

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety
Le Borgne et al (2024) https://doi.org/10.1101/2024.08.20.607920
Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs
Naskar S et al (2021) Cell Rep 34(8) : 108774
PubMedID: 33626343
Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus
Banks PJ et al (2021) Cereb Cortex Commun 2(2) : tgab029
PubMedID: 34296174
Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington's disease
Surmeier et al et al (2021) Research Square https://doi.org/10.21203/rs.3.rs-1008365/v1
Biased Connectivity of Brain-wide Inputs to Ventral Subiculum Output Neurons
Wee and MacAskill. (2020) Cell Rep. 30(11) : 3644-3654
PubMedID: 32187537

Non-selective voltage gated K⁺ channel blocker

Order: HB1073
Pack	Price	Qty
100mg	$69

4-Aminopyridine (4-AP)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for 4-Aminopyridine (4-AP)

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety

Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs

Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus

Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington's disease

Biased Connectivity of Brain-wide Inputs to Ventral Subiculum Output Neurons

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Tell us about your publication!

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4-Aminopyridine (4-AP)

Certificate of Analysis

Latest Certificate of Analysis

Download Batch-Specific CoA

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for 4-Aminopyridine (4-AP)

4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis.

Temporal lobe epileptiform activity following systemic administration of 4-aminopyridine in rats.

Identification of selective inhibitors of the potassium channel Kv1.1-1.2((3)) by high-throughput virtual screening and automated patch clamp.

Different state dependencies of 4-aminopyridine binding to rKv1.4 and rKv4.2: role of the cytoplasmic halves of the fifth and sixth transmembrane segments.

Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety

Cell-type-specific recruitment of GABAergic interneurons in the primary somatosensory cortex by long-range inputs

Plasticity in Prefrontal Cortex Induced by Coordinated Synaptic Transmission Arising from Reuniens/Rhomboid Nuclei and Hippocampus

Cholinergic deficits selectively boost cortical intratelencephalic control of the striatum in Huntington's disease

Biased Connectivity of Brain-wide Inputs to Ventral Subiculum Output Neurons

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Tell us about your publication!

Captcha

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