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Mibefradil dihydrochloride

(HB1226)
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Product overview

Name Mibefradil dihydrochloride
Alternative names Ro 40-5967
Purity >95%
Description Potent, reversible T- / L-type Ca2+ channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Mibefradil dihydrochloride product vial image | Hello Bio
Mibefradil dihydrochloride product vial image | Hello Bio

Mibefradil dihydrochloride product vial image | Hello Bio

Mibefradil dihydrochloride product vial image | Hello Bio

Biological Data

Biological description

Potent and reversible T-type (IC50 = 2.7µM) and L-type (Ki = 18.6µM) Ca2+ channel blocker. Exhibits 10-15-fold selectivity for T-type channels over L-type channels. Cell permeable. Displays antihypertensive and hypoglycemic properties.

Solubility & Handling

Solubility overview Soluble in water (50mM) or DMSO (100mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name (1S,2S)-2-[2-[[3-(1H-Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Molecular Weight 568.56
Chemical structure Mibefradil dihydrochloride [116666-63-8] Chemical Structure
Molecular Formula C29H38FN3O3.2HCl
CAS Number 116666-63-8
PubChem identifier 60662
SMILES Cl.Cl.COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=C(N2)C=CC=C3)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C
InChi InChI=1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H/t28-,29-;;/m0../s1
InChiKey MTJLQTFHJIHXIX-GDUXWEAWSA-N
MDL number MFCD00868314

References for Mibefradil dihydrochloride

References are publications that support the biological activity of the product

  • Mibefradil reduces blood glucose concentration in db/db mice.

    Lu Y et al (2014) Clinics (Sao Paulo) 69(1) : 61-7.
    Read more (PubMedID: 24473561)

  • The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay.

    Major TC et al (2008) J Pharmacol Exp Ther 325(3) : 723-31.
    Read more (PubMedID: 18326812)

  • A mibefradil metabolite is a potent intracellular blocker of L-type Ca(2+) currents in pancreatic beta-cells.

    Wu S et al (2000) J Pharmacol Exp Ther 292(3) : 939-43.
    Read more (PubMedID: 10688607)

3 Item(s)

Grouped product items
Order: HB1226
Pack PriceQty
5mg
$118
10mg
$209
25mg
$495
Potent, reversible T- / L-type Ca2+ channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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