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Images Mibefradil dihydrochloride product vial image | Hello Bio
Mibefradil dihydrochloride product vial image | Hello Bio Biological Data Biological description Potent and reversible T-type (IC50 = 865 nM) and L-type (Ki = 8.2 nM) Ca2+ channel blocker. Exhibits 10-15-fold selectivity for T-type channels over L-type channels. Cell permeable. Displays antihypertensive and hypoglycemic properties.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in water (50mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name (1S ,2S )-2-[2-[[3-(1H -Benzimidazol-2-yl)propyl]methylamino]ethyl]-6-fluoro-1,2,3,4-tetrahydro-1-(1-methylethyl)-2-naphthalenyl methoxyacetoacetate dihydrochloride
Chemical structure
Molecular Formula C29 H38 FN3 O3 .2HCl
SMILES Cl.Cl.COCC(=O)O[C@]1(CCN(C)CCCC2=NC3=C(N2)C=CC=C3)CCC2=C(C=CC(F)=C2)[C@@H]1C(C)C
InChi InChI=1S/C29H38FN3O3.2ClH/c1-20(2)28-23-12-11-22(30)18-21(23)13-14-29(28,36-27(34)19-35-4)15-17-33(3)16-7-10-26-31-24-8-5-6-9-25(24)32-26;;/h5-6,8-9,11-12,18,20,28H,7,10,13-17,19H2,1-4H3,(H,31,32);2*1H/t28-,29-;;/m0../s1
InChiKey MTJLQTFHJIHXIX-GDUXWEAWSA-N
References for Mibefradil dihydrochloride References are publications that support the biological activity of the product
Mibefradil reduces blood glucose concentration in db/db mice. Lu Y et al (2014) Clinics (Sao Paulo) 69(1) : 61-7. The T- and L-type calcium channel blocker (CCB) mibefradil attenuates leg edema induced by the L-type CCB nifedipine in the spontaneously hypertensive rat: a novel differentiating assay. Major TC et al (2008) J Pharmacol Exp Ther 325(3) : 723-31. A mibefradil metabolite is a potent intracellular blocker of L-type Ca(2+) currents in pancreatic beta-cells. Wu S et al (2000) J Pharmacol Exp Ther 292(3) : 939-43.
Potent, reversible T- / L-type Ca2+ channel blocker
![Mibefradil dihydrochloride [116666-63-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1226.png "Mibefradil dihydrochloride [116666-63-8]")
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