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Images Psalmotoxin 1: Scientist Approved
Psalmotoxin 1 product vial image | Hello Bio
Psalmotoxin 1: Scientist Approved Psalmotoxin 1 product vial image | Hello Bio Biological Data Biological description Potent and selective acid sensing (proton gated) ion channel 1a (ASIC1a) blocker (IC50 = 0.9 nM). Shows antinociceptive and neuroprotective actions.
Solubility & Handling Solubility overview Soluble in water (2mg/ml)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Molecular Formula C200 H312 N62 O57 S6
PubChem identifier 90489000
SMILES [H]N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC4=CC=CC=C4)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CSSC[C@H](NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC4=CNC5=C4C=CC=C5)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@@H](NC1=O)[C@@H](C)CC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC1=CNC=N1)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N3)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC2=O)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
InChiKey LICLJUGDURFZIM-UHFFFAOYSA-N
References for Psalmotoxin 1 References are publications that support the biological activity of the product
Neuroprotective effect of acid-sensing ion channel inhibitor psalmotoxin-1 after hypoxia-ischemia in newborn piglet striatum. Yang ZJ et al (2011) Neurobiol Dis 43(2) : 446-54. A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Mazzuca M et al (2007) Nat Neurosci 10(8) : 943-5. Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels. Escoubas P et al (2000) J Biol Chem 275(33) : 25116-21.
Publications
These publications cite the use of Psalmotoxin 1 purchased from Hello Bio:
Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus Mango et al. (2017) Pharmacological Research 119 : 12–19 Acid-sensing ion channel 1a is required for mGlu receptor dependent long-term depression in the hippocampus Mango et al (2017) Pharmacological Research : In press
Potent, selective ASIC1a blocker
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