The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Images ω-Agatoxin IVA product vial image | Hello Bio
ω-Agatoxin IVA product vial image | Hello Bio Biological Data Biological description Potent and selective P-type / Q-type Ca2+ channel blocker (IC50 = <1-3 nM for P type channels). Exhibits reduced potency at N-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.
Solubility & Handling Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical structure
Molecular Formula C217 H360 N68 O60 S10
PubChem identifier 90488780
SMILES CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N
InChi InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34
InChiKey NVVFOMZVLALQKT-UHFFFAOYSA-N
References for ω-Agatoxin IVA References are publications that support the biological activity of the product
Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks. Knaack GL et al (2013) Neurotoxicology 37 : 19-25. Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA. Tringham EW et al (2008) J Pharmacol Exp Ther 324(2) : 806-14. Synthesis of omega-agatoxin IVA and its related peptides. Nishio H et al (1993) Biochem Biophys Res Commun 196(3) : 1447-53.
Publications
These publications cite the use of ω-Agatoxin IVA purchased from Hello Bio:
Calcium-induced calcium release activates spontaneous miniature outward currents in newt medullary reticular formation neurons Yaeger DB et al (2018) J Neurophysiol 120(6) : 3140-3154
Potent, selective P-type / Q-type Ca2+ channel blocker
![ω-Agatoxin IVA [145017-83-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1212_1.png "ω-Agatoxin IVA [145017-83-0]")
Understanding purity and quality - a guide for life scientists
