Product overview
| Name | ω-Agatoxin IVA |
| Description | Potent, selective P-type / Q-type Ca2+ channel blocker |
| Alternative names | ω-Aga-IV A |
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Biological Data
| Biological description | Potent and selective P-type / Q-type Ca2+ channel blocker (IC50 = <1-3 nM for P type channels). Exhibits reduced potency at N-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Molecular Weight | 5202.25 |
| Chemical structure | ![ω-Agatoxin IVA [145017-83-0] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1212_1.png "ω-Agatoxin IVA [145017-83-0]") |
| Molecular Formula | C217H360N68O60S10 |
| CAS Number | 145017-83-0 |
| PubChem identifier | 90488780 |
| SMILES | CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N |
| InChi | InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34 |
| InChiKey | NVVFOMZVLALQKT-UHFFFAOYSA-N |
| MDL number | MFCD00165055 |
References for ω-Agatoxin IVA
References are publications that support the biological activity of the product
-
Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks.
Knaack GL et al (2013) Neurotoxicology 37 : 19-25. -
Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA.
Tringham EW et al (2008) J Pharmacol Exp Ther 324(2) : 806-14. -
Synthesis of omega-agatoxin IVA and its related peptides.
Nishio H et al (1993) Biochem Biophys Res Commun 196(3) : 1447-53.
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