Product overview

Name ω-Agatoxin IVA
Alternative names ω-Aga-IV A
Purity >95%
Description

Potent, selective P-type / Q-type Ca2+ channel blocker

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ω-Agatoxin IVA product vial image | Hello Bio

Biological Data

Biological description Potent and selective P-type / Q-type Ca2+ channel blocker (IC50 = <1-3 nM for P type channels). Exhibits reduced potency at N-type Ca2+ channels. Found in the venom of the funnel web spider Agelenopsis aperta.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Molecular Weight 5202.25
Chemical structure ω-Agatoxin IVA  [145017-83-0] Chemical Structure
Molecular Formula C217H360N68O60S10
CAS Number 145017-83-0
PubChem identifier 90488780
SMILES CCC(C)C1C(=O)NC2CSSCC(C(=O)NC(C(=O)NC(CSSCC3C(=O)NC4CSSCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(CSSCC(C(=O)N1)NC(=O)CNC(=O)C(NC(=O)CNC(=O)C(NC4=O)CCCNC(=N)N)CCCNC(=N)N)C(=O)NC(C(=O)NC(C(=O)NCC(=O)NCC(=O)NC(C(=O)N5CCCC5C(=O)N3)C(C)O)CC6=CNC7=CC=CC=C76)CCCCN)CCCNC(=N)N)CC8=CC=C(C=C8)O)CC(=O)O)CCCCN)C)C(C)CC)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCCN)N)C(=O)NC(CCCCN)C(=O)N9CCCC9C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(C(C)CC)C(=O)NC(CCSC)C(=O)NC(CCC(=O)O)C(=O)NCC(=O)NC(CC(C)C)C(=O)NCC(=O)NC(CC(C)C)C(=O)NC(C)C(=O)O)CCC(=O)O)NC(=O)C(NC(=O)C(NC(=O)CNC(=O)C(NC(=O)C(NC(=O)C(NC2=O)CO)C(C)CC)CCSC)C(C)O)CC(=O)N
InChi InChI=1S/C217H360N68O60S10/c1-21-111(11)168-206(337)247-115(15)174(305)254-128(48-28-34-70-219)185(316)268-144(89-167(303)304)193(324)266-141(86-119-59-61-121(289)62-60-119)181(312)246-94-159(293)250-127(55-41-77-236-216(230)231)183(314)271-147-101-349-34
InChiKey NVVFOMZVLALQKT-UHFFFAOYSA-N
MDL number MFCD00165055

References for ω-Agatoxin IVA

References are publications that support the biological activity of the product
  • Differential responses to ω-agatoxin IVA in murine frontal cortex and spinal cord derived neuronal networks.

    Knaack GL et al (2013) Neurotoxicology 37 : 19-25.
  • Protease treatment of cerebellar purkinje cells renders omega-agatoxin IVA-sensitive Ca2+ channels insensitive to inhibition by omega-conotoxin GVIA.

    Tringham EW et al (2008) J Pharmacol Exp Ther 324(2) : 806-14.
  • Synthesis of omega-agatoxin IVA and its related peptides.

    Nishio H et al (1993) Biochem Biophys Res Commun 196(3) : 1447-53.

3 Item(s)

Publications
These publications cite the use of ω-Agatoxin IVA purchased from Hello Bio:
  • Calcium-induced calcium release activates spontaneous miniature outward currents in newt medullary reticular formation neurons

    Yaeger DB et al (2018) J Neurophysiol 120(6) : 3140-3154
    PubMedID: 29897864

1 Item