GluN2C

Non-competitive AMPA receptor antagonist. Also blocks kainate GluK3 homomeric receptors.

Selective TRPC6 channel activator and neurotransmitter re-uptake inhibitor

Non-selective endogenous glycine receptor agonist 

Potent, reversible, selective K_Ca channel inhibitor

Potent, selective Na_v1.3 / Na_v1.1 channel inhibitor

Potent TRPM8 channel agonist

Piezo1 channel activator

Prototypic, selective kainate receptor agonist. Potent excitant and neurotoxin.

Endogenous ionotropic glutamate / nicotinic antagonist.

Na²⁺ / K⁺ / Ca²⁺ channel inhibitor. Anticonvulsant.