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Icilin

(HB1153)
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Product overview

Name Icilin
Alternative names AG 3-5
Purity >95%
Description Potent TRPM8 channel agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Icilin product vial image | Hello Bio
Icilin product vial image | Hello Bio

Icilin product vial image | Hello Bio

Icilin product vial image | Hello Bio

Biological Data

Biological description Potent TRPM8 channel agonist. Approx 200-fold more potent than methanol (EC50 values of 0.36 and 66.7 µM for icilin and methanol respectively). Cooling agent that also activates TRPA1 cold channel. Also TRPV3 channel inhibitor (IC50 = 0.5 µM).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name 3,4-Dihydro-3-(2-hydroxyphenyl)-6-(3-nitrophenyl)-(1H)-pyrimidin-2-one
Molecular Weight 311.3
Chemical structure Icilin [36945-98-9] Chemical Structure
Molecular Formula C16H13N3O4
CAS Number 36945-98-9
PubChem identifier 161930
SMILES OC1=C(C=CC=C1)N1CC=C(NC1=O)C1=CC=CC(=C1)[N+]([O-])=O
InChiKey RCEFMOGVOYEGJN-UHFFFAOYSA-N

References for Icilin

References are publications that support the biological activity of the product

  • Supercooling agent icilin blocks a warmth-sensing ion channel TRPV3.

    Sherkheli MA et al (2012) ScientificWorldJournal 2012 : 982725
    Read more (PubMedID: 22548000)

  • Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay.

    Behrendt HJ et al (2004) Br J Pharmacol 141(4) : 737-45.
    Read more (PubMedID: 14757700)

  • ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures.

    Story GM et al (2003) Cell 112(6) : 819-29.
    Read more (PubMedID: 12654248)

  • Identification of a cold receptor reveals a general role for TRP channels in thermosensation.

    McKemy DD et al (2002) Nature 416(6876) : 52-8.
    Read more (PubMedID: 11882888)

4 Item(s)

Grouped product items
Order: HB1153
Pack PriceQty
10mg
$136
50mg
$543
Potent TRPM8 channel agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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