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Images Kynurenic acid: Scientist Approved
Kynurenic acid product vial image | Hello Bio
Kynurenic acid: Scientist Approved Kynurenic acid product vial image | Hello Bio Biological Data Biological description Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (75mM) and in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 4-Hydroxyquinoline-2-carboxylic acid
Chemical structure
Molecular Formula C10 H7 NO3
SMILES C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
InChi InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChiKey HCZHHEIFKROPDY-UHFFFAOYSA-N
References for Kynurenic acid References are publications that support the biological activity of the product
Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells. Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6. Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro. Alt et al (2004) Neuropharmacology 46(6) : 793-806 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones. Weber M et al (2001) J Neurochem 77(4) : 1108-15. Kynurenate is neuroprotective following experimental brain injury in the rat. Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.
Publications
These publications cite the use of Kynurenic acid purchased from Hello Bio:
Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory Davenport CM et al (2021) Neuron 109(1) : 123-134.e4
Endogenous ionotropic glutamate / nicotinic antagonist.
![Kynurenic acid [492-27-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0362.png "Kynurenic acid [492-27-3]")
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