Kynurenic acid

Name: Kynurenic acid
Brand: Hello Bio
SKU: HB0362
Price: 36 USD
Availability: InStock
Rating: 100 (2 reviews)

(HB0362)

Publications (1)

Technical documents: SDS CoA Datasheet

2 Reviews

Top Reviews:

100% of 100

Product overview

Name

Kynurenic acid

Alternative names

Kynurenate; KYNA

Purity

>98%

Description

Endogenous ionotropic glutamate / nicotinic antagonist.

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (2) Reviews (2) Publications (1) References (4) Frequently bought together

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Images

Kynurenic acid: Scientist Approved

Kynurenic acid product vial image | Hello Bio

Kynurenic acid product vial image | Hello Bio

Biological Data

Biological description

Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties.

Solubility & Handling

Solubility overview

Soluble in DMSO (75mM) and in 0.1M NaOH (100mM)

Storage instructions

Room temperature

Storage of solutions

Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.

Shipping Conditions

Stable for ambient temperature shipping. Follow storage instructions on receipt.

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

4-Hydroxyquinoline-2-carboxylic acid

Molecular Weight

189.17

Chemical structure

Molecular Formula

C₁₀H₇NO₃

CAS Number

492-27-3

PubChem identifier

3845

SMILES

C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O

InChi

InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)

InChiKey

HCZHHEIFKROPDY-UHFFFAOYSA-N

MDL number

MFCD00006753

Appearance

White solid

Technical guides

Ionotropic glutamate receptor nomenclature guide

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Kynurenic acid

References are publications that support the biological activity of the product

Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells.
Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6.
Read more (PubMedID: 24905318)
Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.
Alt et al (2004) Neuropharmacology 46(6) : 793-806
Read more (PubMedID: 15033339)
6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.
Weber M et al (2001) J Neurochem 77(4) : 1108-15.
Read more (PubMedID: 11359876)
Kynurenate is neuroprotective following experimental brain injury in the rat.
Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.
Read more (PubMedID: 7812795)

Publications

Submit Yours Now

These publications cite the use of Kynurenic acid purchased from Hello Bio:

Relocation of an Extrasynaptic GABA_A Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory
Davenport CM et al (2021) Neuron 109(1) : 123-134.e4
PubMedID: 33096025

Endogenous ionotropic glutamate / nicotinic antagonist.

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Order: HB0362
Pack	Price	Qty
250mg	$36
1g	$56
5g	$164