Kynurenic acid

(HB0362)
Technical documents: SDS CoA Datasheet

Product overview

Name Kynurenic acid
Description Endogenous ionotropic glutamate / nicotinic antagonist.
Alternative names Kynurenate; KYNA
Purity >98%
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Kynurenic acid: Scientist Approved

Biological Data

Biological description Endogenous, non-selective ionotropic glutamate receptor antagonist which acts as a non-competitive glycine site NMDAR antagonist. Also an α7 nicotinic receptor antagonist and GPR35 ligand. Blocks kainic acid neurotoxicity and displays neuroprotective, antiproliferative and antimigrative properties.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (75mM) and in 0.1M NaOH (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 4-Hydroxyquinoline-2-carboxylic acid
Molecular Weight 189.17
Chemical structure Kynurenic acid  [492-27-3] Chemical Structure
Molecular Formula C10H7NO3
CAS Number 492-27-3
PubChem identifier 3845
SMILES C1=CC=C2C(=C1)C(=O)C=C(N2)C(=O)O
InChi InChI=1S/C10H7NO3/c12-9-5-8(10(13)14)11-7-4-2-1-3-6(7)9/h1-5H,(H,11,12)(H,13,14)
InChiKey HCZHHEIFKROPDY-UHFFFAOYSA-N
MDL number MFCD00006753
Appearance White solid

References for Kynurenic acid

References are publications that support the biological activity of the product
  • Kynurenic acid inhibits proliferation and migration of human glioblastoma T98G cells.

    Walczak K et al (2014) Pharmacol Rep 66(1) : 130-6.
  • Pharmacological characterization of glutamatergic agonists and antagonists at recombinant human homomeric and heteromeric kainate receptors in vitro.

    Alt et al (2004) Neuropharmacology 46(6) : 793-806
  • 6-Hydroxykynurenic acid and kynurenic acid differently antagonise AMPA and NMDA receptors in hippocampal neurones.

    Weber M et al (2001) J Neurochem 77(4) : 1108-15.
  • Kynurenate is neuroprotective following experimental brain injury in the rat.

    Hicks RR et al (1994) Brain Res 655(1-2) : 91-6.
Publications
These publications cite the use of Kynurenic acid purchased from Hello Bio:
  • Relocation of an Extrasynaptic GABAA Receptor to Inhibitory Synapses Freezes Excitatory Synaptic Strength and Preserves Memory

    Davenport CM et al (2021) Neuron 109(1) : 123-134.e4
    PubMedID: 33096025

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