Histone deacetylase (HDAC)

Histone acetylation is a key epigenetic process - it is upregulated during memory formation but downregulated in numerous neurodegenerative diseases (eg. Alzheimer's disease and Huntington's disease). There are 18 Histone Deacetylase (HDAC) enzymes that are classified into two groups, the histone deacetylase family and the sirtuin family. The histone deacetylase family is further divided into classes I, II and IV. HDAC inhibitors are a class of compounds that increase acetylation of lysine residues on histone proteins as well as other, nonhistone, proteins by inhibiting the activity of these HDAC enzymes. Researchers can save up to 50% on HDAC inhibitors from Hello Bio - they are up to half the price of other suppliers.

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  1. Arctigenin (HB0119)

    Description:

    Potent MAP kinase kinase (MKK/MEK) inhibitor

    Purity:

    >98%

    Pack:
    25mg
    Price:
    $154
    Qty:
    Pack:
    50mg
    Price:
    $298
    Qty:
    Pack:
    100mg
    Price:
    $462
    Qty:
  2. Description:

    Reversible protein transport inhibitor. Commonly used in cytokine staining. Enhances CRISPR-mediated HDR.

    Purity:

    >98%

    Pack:
    5mg
    Price:
    $110
    Qty:
    Pack:
    25mg
    Price:
    $481
    Qty:
  3. Pack:
    10μg
    Price:
    $182
    Qty:
  4. Description:

    Serine protease inhibitor. Inhibits TMPRSS2 and partially blocks SARS-Cov2 entry in vitro.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    Qty:
    Pack:
    50mg
    Price:
    $154
    Qty:
  5. Pack:
    1g
    Price:
    $34
    Qty:
    Pack:
    5g
    Price:
    $67
    Qty:
  6. CHIR 99021 (HB1261)

    Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons.

    Purity:

    >98%

    Pack:
    1mg
    Price:
    $50
    Qty:
    Pack:
    2mg
    Price:
    Qty:
    Pack:
    5×2mg
    Price:
    $188
    Qty:
    Pack:
    10mg
    Price:
    $182
    Qty:
    Pack:
    5mg
    Price:
    $117
    Qty:
    Pack:
    25mg
    Price:
    $445
    Qty:
    Pack:
    50mg
    Price:
    $758
    Qty:
    Pack:
    10mM (1mL in DMSO)
    Price:
    $126
    Qty:
  7. Description:

    Potent, selective GSK3 inhibitor and Wnt signaling activator. Commonly used in organoid production and involved in reprogramming MEFs to IPSCs and fibroblasts to mature neurons. Water soluble.

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $229
    Qty:
    Pack:
    50mg
    Price:
    $916
    Qty:
  8. Description:

    STAT3 inhibitor

    Purity:

    >98%

    Pack:
    10mg
    Price:
    $83
    Qty:
    Pack:
    25mg
    Price:
    $205
    Qty:
    Pack:
    50mg
    Price:
    $376
    Qty:
    Pack:
    100mg
    Price:
    $677
    Qty:
  9. Cyclosporin A (HB0220)

    Description:

    Potent calcineurin inhibitor. Inhibits MPTP opening.

    Purity:

    >99%

    Pack:
    100mg
    Price:
    $100
    Qty:
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