Product overview

Name Calyculin A
Alternative names CA
Purity >98%
Description Potent, selective protein phosphatase 1 / 2A inhibitor
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Biological Data

Biological description Potent and selective protein phosphatase 1 and 2A catalytic subunit inhibitor (IC50 values are 2 and 0.5 - 1 nM respectively). Inhibits smooth muscle myosin B phosphatase catalytic subunit (IC50 = 0.7 nM). Thought to act a as a calcium channel blocker, blocks intracellular calcium increase and prevents cell cycle progression. Shows Alzheimer's disease-like actions; causes tau protein hyperphosphorylation and impairs spacial memory retention.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S, 9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-di hydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
Molecular Weight 1009.18
Chemical structure Calyculin A  [101932-71-2] Chemical Structure
Molecular Formula C50H81N4O15P
CAS Number 101932-71-2
PubChem identifier 5311365
SMILES C[C@H]1[C@@H](C[C@@]2(C([C@H]([C@H](O2)[C@H](C[C@@H]([C@H](C)[C@@H]([C@H](C)/C=C(\C)/C(=C/C=C/C(=C\C#N)/C)/C)O)O)OC)OP(=O)(O)O)(C)C)O[C@H]1C/C=C/C3=COC(=N3)[C@@H](C)CCNC(=O)[C@H]([C@H]([C@H](COC)N(C)C)O)O)O
InChi InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-
MDL number MFCD06795864

References for Calyculin A

References are publications that support the biological activity of the product
  • Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.

    Holy M et al (2012) Toxins (Basel) 4(10) : 940-54.
  • Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.

    Yang X et al (2011) J Psychopharmacol 25(8) : 1118-25.
  • Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.

    Ishihara H et al (1989) Biochem Biophys Res Commun 159(3) : 871-7.

3 Item(s)