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Calyculin A

(HB0161)
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Product overview

Name Calyculin A
Alternative names CA
Purity >98%
Description Potent, selective protein phosphatase 1 / 2A inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective protein phosphatase 1 and 2A catalytic subunit inhibitor (IC50 values are 2 and 0.5 - 1 nM respectively). Inhibits smooth muscle myosin B phosphatase catalytic subunit (IC50 = 0.7 nM). Thought to act a as a calcium channel blocker, blocks intracellular calcium increase and prevents cell cycle progression. Shows Alzheimer's disease-like actions; causes tau protein hyperphosphorylation and impairs spacial memory retention.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name N-[(3S)-[4-(1E)-3-[(2R,3R,4R,7S,8S, 9R)-2-[(1S,3S,4S,5R,7E,9E,11E,13Z)-14-Cyano-3,5-di hydroxy-1-methoxy-4,6,8,9,13-pentamethyl-7,9,11,13-tetradecatetraenyl]-9-hydroxy-4,4,8-trimethyl-3-(phosphonooxy)-1,6-dioxaspiro[4.5]dec-7-yl]-1-propenyl]-2-oxazoly]butyl]-4-deoxy-4-(dimethylamino)-5-O-methyl-L-ribonamide
Molecular Weight 1009.18
Chemical structure Calyculin A [101932-71-2] Chemical Structure
Molecular Formula C50H81N4O15P
CAS Number 101932-71-2
PubChem identifier 5311365
SMILES C[C@H]1[C@@H](C[C@@]2(C([C@H]([C@H](O2)[C@H](C[C@@H]([C@H](C)[C@@H]([C@H](C)/C=C(\C)/C(=C/C=C/C(=C\C#N)/C)/C)O)O)OC)OP(=O)(O)O)(C)C)O[C@H]1C/C=C/C3=COC(=N3)[C@@H](C)CCNC(=O)[C@H]([C@H]([C@H](COC)N(C)C)O)O)O
InChi InChI=1S/C50H81N4O15P/c1-29(20-22-51)16-14-17-30(2)32(4)24-33(5)42(57)35(7)38(55)25-41(65-13)45-46(69-70(61,62)63)49(8,9)50(68-45)26-39(56)34(6)40(67-50)19-15-18-36-27-66-48(53-36)31(3)21-23-52-47(60)44(59)43(58)37(28-64-12)54(10)11/h14-18,20,24,27,31,33-
InChiKey FKAWLXNLHHIHLA-YCBIHMBMSA-N
MDL number MFCD06795864

References for Calyculin A

References are publications that support the biological activity of the product

  • Calyculin A from Discodermia calyx is a dual action toxin that blocks calcium influx and inhibits protein Ser/Thr phosphatases.

    Holy M et al (2012) Toxins (Basel) 4(10) : 940-54.
    Read more (PubMedID: 23162706)

  • Melatonin ameliorates Alzheimer-like pathological changes and spatial memory retention impairment induced by calyculin A.

    Yang X et al (2011) J Psychopharmacol 25(8) : 1118-25.
    Read more (PubMedID: 20542922)

  • Calyculin A and okadaic acid: inhibitors of protein phosphatase activity.

    Ishihara H et al (1989) Biochem Biophys Res Commun 159(3) : 871-7.
    Read more (PubMedID: 2539153)

3 Item(s)

Grouped product items
Order: HB0161
Pack PriceQty
10μg
$175
Potent, selective protein phosphatase 1 / 2A inhibitor
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Hazardous: $35

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